Cytidine Mediated AuAg Nanoclusters as Bright Fluorescent Probe for Tumor Imaging in vivo
Cytidine Mediated AuAg Nanoclusters as Bright Fluorescent Probe for Tumor Imaging in vivo作者机构：State Key Laboratory of Bioelectronics ( Chien-Shiung Wu Laboratory) Southeast University Nanjing Jiangsu 210096 China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2016年第34卷第6期
页 面：589-593页
核心收录：
学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 071009[理学-细胞生物学] 09[农学] 0703[理学-化学] 0901[农学-作物学] 090102[农学-作物遗传育种]
基 金：supported by National High Technology Research & Development Program of China 国家自然科学基金 the Major Science & Technology Project of Suzhou
主 题：fluorescence bioimaging cytidine mediated AuAg nanoclusters tumor bio-labeling
摘 要：Noble metal clusters is an emerging class of fluorescent probes, avoiding most of the drawbacks of common fluorescent compounds, and they are simple to prepare and have good water solubility, good biocompatibility and excellent fluorescence properties. In this study, we have explored the synthesis of the cytidine mediated gold-silver nanoclusters （AuAg NCs） and applied it for both in vitro cellular imaging and tumor in vivo detection. Experimental results show that the as-prepared AuAg NCs can be used as a sensitive fluorescent probe for cancer cells/tissue de- tection. Especially, it is evident that under the relevant light irradiation with the wavelength of 488 nm, obviously bright fluorescence signal could be readily detected from focus location of inoculating tumor mouse, implying its possible application for the effective in vivo tumor bioimaging.
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