Relationship of VEGF/VEGFR with immune and cancer cells:staggering or forward?

作     者：Yu-Ling Li Hua Zhao Xiu-Bao Ren 

作者机构：Department of Biotherapy Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Immunology and BiotherapyResearch Center of Lung Cancer 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2016年第13卷第2期

页      面：206-214页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the key program of the National Basic Research Program of China (973 program) (Grant No. 2012CB9333004) the National Natural Science Foundation of China (Grant No. 81401888) 

主　　题：血管内皮生长因子受体 免疫细胞 VEGF 癌细胞 树突状细胞 血管生成因子 分泌途径 环境信号 

摘      要：Vascular endothelial growth factor(VEGF) is primarily known as a proangiogenic factor and is one of the most important growth and survival factors affecting the vascular endothelium. However, recent studies have shown that VEGF also plays a vital role in the immune environment. In addition to the traditional growth factor role of VEGF and VEGF receptors(VEGFRs), they have a complicated relationship with various immune cells. VEGF also reportedly inhibits the differentiation and function of immune cells during hematopoiesis. Dendritic cells(DCs), macrophages, and lymphocytes further express certain types of VEGF receptors.VEGF can be secreted as well by tumor cells through the autocrine pathway and can stimulate the function of cancer stemness.This review will provide a paradigm shift in our understanding of the role of VEGF/VEGFR signaling in the immune and cancer environment.