Investigation of long-term implantation of BuMA stent in a porcine coronary model

作     者：CHEN Ming WANG Xin-gang ZHENG Bo PENG Hong-yu Zhang Xiao-yan ZHANG Bin HUO Yong 

作者机构：Peking Univ Hosp 1 Dept Cardiol Beijing 100034 Peoples R China Beijing Anzhen Hosp Dept Cardiol Beijing 100029 Peoples R China Peking Univ Dept Cardiol Shougang Hosp Beijing 100144 Peoples R China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2012年第125卷第22期

页      面：4083-4087页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 0905[农学-畜牧学] 08[工学] 09[农学] 090501[农学-动物遗传育种与繁殖] 10[医学] 

主　　题：biodegradable polymer electro-grafting base layer drug-eluting stent porcine coronary model 

摘      要：Background Stent-based delivery of sirolimus has been shown to reduce neointimal hyperplasia significantly. However, the long-term effect of the polymer is thought to initiate and sustain an inflammatory response and contribute to the occurrence of late complications. Our study aimed to evaluate the efficacy and safety of the BuMA biodegradable drug-coated sirolimus-eluting stent （BSES） for inhibiting neointimal hyperplasia in a porcine coronary model. Methods Four types of stents were implanted at random in different coronary arteries of the same pig： BSES （n=24）, bare metal stent （BMS） （n=24）, biodegradable polymer coated stent without drug （PCS） （n=24） and only poly （n-butyl methacrylate） base layer coated stent （EGS） （n=23）. In total, 26 animals underwent successful random placement of 95 oversized stents in the coronary arteries. Coronary angiography was performed after 28 days, 90 days and 240 days of stent implantation. After 14 days, 28 days, 90 days and 240 days, 6 animals at each timepoint were sacrificed for histomorphologic analysis. Results The 28-day, 90-day and 240-day results of quantitative coronary angiography （QCA） showed reduction in luminal loss （LL） in the BSES group when compared with the BMS group; （0.20±0.35） mm vs. （0.82±0.51） mm （P=-0.035）, （0.20±0.30） mm vs. （0.93±0.51） mm （P=-0.013）, and （0.18±0.16） mm vs. （0.19±0.24） mm （P=0.889）, respectively. By 28-day, 90-day and 240-day histomorphomeric analysis results, there was also a corresponding significant reduction in neointimal tissue proliferation with similar injury scores of BSES compared with the BMS control; average neointimal area （0.90±0.49） mm2 vs. （2.16±1.29） mm2 （P=0.049）, （1.53±0.84） mm2 vs. （3.41±1.55） mm2 （P=-0.026）, and （2.43±0.95） mm2 vs. （3.12±1.16） mm2 （P=0.228）, respectively. High magnification histomorphologic examination revealed similar inflammation scores and endothelialization scores in both the BSES and BMS groups. Conclusions The BuMA biodegradable drug-coated sirol