卵巢功能早衰的不孕症患者采用半人工周期治疗在体外受精及胚胎移植中的作用

作     者：Branco A.C. Achour-Frydman N. Kadoch J. R. Frydman 张剑萍 

作者机构：Dr. Department of Obstetrics and Gynecology and Reproductive Medicine Hpital Antoine Béclère 157 rue de la Porte de Trivaux 92141 Clamart France 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2006年第2卷第2期

页      面：27-27页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

主　　题：卵巢功能早衰 人工周期治疗 体外受精 月经周期 临床妊娠率 种植率 卵泡发育 卵巢储备功能 卵母细胞 

摘      要：Objective: To investigate whether seminatural cycle is a reasonable management for ovarian aging patients. Design: Prospective study. Setting: ART Unit, Clamart, France. Patient(s): Seventy-five women, 158 cycles. Intervention(s): Infertile women who presented with ovarian aging (defined as low ovarian reserve and characterized by cycle day 3 high FSH, high E2, and/or low inhibin B and/or previous cycle cancellations due to poor ovarian response to COH) were studied. Patients were offered up to three cycles. Treatment was scheduled as follows. From cycle day 8 onward the selection of the dominant follicle was monitored by ultrasound and hormonal measurements. When the dominant follicle appeared, patients received GnRH antagonist and, thereafter, hMG to support further follicular development. Main Outcome Measure(s): Implantation rate and clinical pregnancy. Result(s): Twenty-eight of 158 cycles were cancelled (17.7%). Oocyte pickups were performed in 119 (75.3%) cycles, 91 (57.6%) mature oocytes were retrieved, and 67 (42.4%) embryos transferred. Nineteen clinical pregnancies were obtained; the cumulative pregnancy rate per patient, after 3 cycles, was 35.2%. Conclusion(s): Use of a seminatural cycle is a reasonable management for patients with ovarian aging who have ovulatory menstrual cycles. It achieves a high implantation rate (28.3%).