Precursor-involved and Conversion Rate-controlled Self-assembly of a ＇Super Gelator＇ in Thixotropic Hydrogels for Drug Delivery

作     者：区彩文 王怀民 杨志谋 陈敏生 

作者机构：Guangzhou Medical UniversityGuangzhouGuangdong 510182China State Key Laboratory of Medicinal Chemical Biology and College of Life SciencesNankai UniversityTianjin 300071China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2012年第30卷第8期

页      面：1781-1787页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 0809[工学-电子科学与技术（可授工学、理学学位）] 07[理学] 070205[理学-凝聚态物理] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 083201[工学-食品科学] 0702[理学-物理学] 

基　　金：国家自然科学基金 

主　　题：self-assembly hydrogel enzymatic reaction 

摘      要：Enzymatic hydrogelation is a totally different process to the heating-cooling gelation process, in which the pre- cursors of the gelators can be involved during the formation of self-assembled structures. Using thixotropic hy- drogels formed by a super gelator as our studied system, we demonstrated that the enzyme concentration/conversion rate of enzymatic reaction had a strong influence on the morphology of resulting self-assembled nanostructures and the property of resulting hydrogels. The principle demonstrated in this study not only helps to understand and elucidate the phenomenon of self-assembly triggered by enzymes in biological systems, but also offers a unique methodology to control the morphology of self-assembled structures for specific applications such as controlled drug re- lease.