Gastric juice acidity in upper gastrointestinal diseases
Gastric juice acidity in upper gastrointestinal diseases作者机构：Institute of Clinical Medicine National Cheng Kung University Division of Gastroenterology Department of Internal Medicine Kaohsiung Veterans General Hospital National Yang-Ming University Genomics Research Center Academic Sinica Department of Pathology Kaohsiung Veterans General Hospital and National Yang-Ming University Division of Gastroenterology Chang Gung Memorial Hospital Kaohsiung Medical Center College of Medicine Chang Gung University
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2010年第16卷第43期
页 面：5496-5501页
核心收录：
基 金：Supported by Research grant NSC-96-2314-B-075B-009 from the National Science Council Taiwan
主 题：Acidity Gastric juice Gastric cancer Peptic ulcer Esophageal ulcer
摘 要：AIM: To search the independent factors determining gastric juice acidity and to investigate the acidity of gastric juices in various benign and malignant upper gastrointestinal diseases. METHODS: Fasting gastric juice acidity of 165 healthysubjects and 346 patients with esophageal ulcer (n = 21), gastric ulcer (n = 136), duodenal ulcer (n = 100) or gastric cancer (n = 89) were measured and compared. Additionally, gastric specimens were taken from the antrum and body for rapid urease test and histological examination. RESULTS: Multivariate analysis revealed that bile stain of gastric juice, high acute inflammatory score of the corpus, and atrophy of the corpus were independent risk factors for the development of gastric hypoacidity with odds ratios of 3.1 (95% CI: 1.3-7.3), 3.1 (95% CI: 1.2-7.9) and 3.5 (95% CI: 1.3-9.2). Esophageal ulcer and duodenal ulcer patients had a lower pH level (1.9 and 2.1 vs 2.9, both P 0.05) of gastric juices than healthy subjects. In contrast, gastric ulcer and gastric cancer patients had a higher pH level (3.4 and 6.6 vs 2.9, both P 0.001) than healthy controls. Hypoacidity existed in 22%, 5%, 29%, 5% and 88% of healthy subjects, esophageal ulcer, gastric ulcer, duodenal ulcer and gastric cancer patients, respectively. CONCLUSION: Bile reflux, atrophy and dense neutrophil infiltrate of the corpus are three independent factors determining the acidity of gastric juice.
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