The relationship of Imp2 and DR3 genes with susceptibility to type Ⅰ diabetes mellitus in south China Han population

作     者：Ding HL Cheng H Fu ZZ Deng QL Yan L Yan T 

作者机构：Department of EndocrinologySun Yat-Sen Memorial HospitalSun Yat-Sen University of Medical SciencesGuangzhou 510120China 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2000年第6卷第1期

页      面：111-114页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Subject headings diabetes mellitus Imp2 genes DR3 genes polymerase chain reaction restriction fragment length polymorphism genetic susceptibility 

摘      要：AIN To study the relationship of Imp2 and DR3genes with type Ⅰ diabetes *** Imp2 genotypes and DR3 wereidentified in 68 patients with type Ⅰ diabetesmellitus(Ⅰ-DM)and 71 healthy ***,Ⅰ-DM patients and controls were respectivelyallocated into DR3-positive and *** frequencies of Imp2 and DR3 genein random subjects,and Imp2 genotypes in DR3-matched subjects were compared between Ⅰ-DMpatients and *** the same time,Ⅰ-DMpatients were divided into 3 groups based on theonset age of diabetics:group A≤14 years,group B 15-30 years and group C≥31 *** The frequency of DR3 in Ⅰ-DMpatients was significantly higher than that incontrols(47% vs 21%,P0.005),and it wassignificantly higher in group A than that in groupB+C(70% vs 36%,x^2=7.07,P0.01).Therewas a significant difference among groups withdifferent onset age of diabetics(x^2=8.19,rp=0.33,P0.05).In random subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(43% vs 61%,P0.05)and Imp2.R/Hhigher(53% vs 28%,P0.05)than that incontrols,and there was no significant differenceamong groups with different onset age *** DR3-positive subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(47% vs 87%,P0.05)and Imp2-R/H higher(47% vs 13%,P0.05)than that *** DR3-negative subjects,thefrequency of Imp2.R/H in Ⅰ-DM patients washigher than that in controls(58% vs 32%,P0.01),but the frequency of Imp2-R/R and Imp2H/H was not significantly different betweenthese two *** DR3 gene may be one of thesusceptible genes of Ⅰ-DM,and significantlyrelated to the onset age of diabetics,and thepersons with DR3 may have an younger onsetage of *** Imp2-R/R may be theprotective genotype of Ⅰ-DM,and Imp2-R/H thesusceptible *** were not affectedby DR3 ***-2 genotypes were not relatedwith the onset age of diabetics.