Phase I/II enzyme gene polymorphisms and esophageal cancer risk: A meta-analysis of the literature

作     者：Chun-XiaYang KeitaroMatsuo Zhi-MingWang KazuoTajima 

作者机构：DepartmentofEpidemiologyHuaxiPublicHealthSchoolSichuanUniversityChengdu610041SichuanProvinceChina//DivisionofEpidemiologyandPreventionAichiCancerCenterResearchInstituteNagoya464-8681Japan DivisionofEpidemiologyandPreventionAichiCancerCenterResearchInstituteNagoya464-8681Japan HuaxiPublicHealthSchoolSichuanUniversityChengdu610041SichuanProvinceChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2005年第11卷第17期

页      面：2531-2538页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Special Japan-China Sasakawa Medical Fellowship 

主　　题：食道肿瘤 基因多态性 病理机制 编码基因 

摘      要：AIM: Phase Ⅰ/Ⅱ enzymes metabolize environmental carcinogens and several functional polymorphisms have been reported in their encoding genes. Although their significance with regard to esophageal carcinogenicity has been examined epidemiologically, it remains controversial. The present systematic review of the literature was performed to clarify ***: Eligible studies were case-control or cohort studies published until September 2004 that were written in any language. From PubMed and a manual review of reference lists in relevant review articles, we obtained 16 studies related to the CYP1A1 Ile-Val substitution in exon 7, CYP1A1MspI polymorphisms, CYP2E1 RsaI polymorphisms,GSTM1 null type, GSTT1 null type and GSTP1 *** were of case-control design. Summary statistics were odds ratios (ORs) comparing heterozygous-, homozygousnon-wild type or these two in combination with the homozygous wild type, or the null type with the non-null type for GSTM1 and GSTT1. A random effect model was used to estimate the summary ORs. A meta-regression analysis was applied to explore sources of heterogeneity. RESULTS: Individuals with the Ile-Val substitution in CYP1A1 exon 7 had increased esophageal cancer risk,with ORs (95%CI) compared with Ile/Ile of 1.37 (1.09-1.71),2.52 (1.62-3.91) and 1.44 (1.17-1.78) for Ile-Val, Val/Val genotype and the combined group. No significant association was found between esophageal cancer risk and the other genetic ***: A significant association exists between the CYP1A1 Ile-Val polymorphism and risk of esophageal cancer. Polymorphisms that increase the internal exposure to activated carcinogens may increase the risk of esophageal cancer.