Molecular mechanisms of coronavirus RNA capping and methylation

作     者：Yu Chen Deyin Guo 

作者机构：State Key Laboratory of Virology College of Life Sciences Wuhan University 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2016年第31卷第1期

页      面：3-11页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：supported by the China "973" Basic Research Program (2013CB911101) China NSFC grants (81130083 and 81271817) 

主　　题：coronavirus RNA capping triphosphatase guanylyltransferase methyltransferase cap structure methylation 

摘      要：The 5′-cap structures of eukaryotic m RNAs are important for RNA stability, pre-m RNA splicing,m RNA export, and protein translation. Many viruses have evolved mechanisms for generating their own cap structures with methylation at the N7 position of the capped guanine and the ribose 2′-Oposition of the first nucleotide, which help viral RNAs escape recognition by the host innate immune system. The RNA genomes of coronavirus were identified to have 5′-caps in the early1980 s. However, for decades the RNA capping mechanisms of coronaviruses remained *** 2003, the outbreak of severe acute respiratory syndrome coronavirus has drawn increased attention and stimulated numerous studies on the molecular virology of coronaviruses. Here, we review the current understanding of the mechanisms adopted by coronaviruses to produce the 5′-cap structure and methylation modification of viral genomic RNAs.