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Erythrocyte and plasma Ca^(2+),Mg^(2+) and cell membrane adenosine triphosphatase activity in patients with essential hypertension

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Chinese Medical Journal 1998年第2期 51-53页

作者：符云峰王素敏卢振敏李红李素琴

Objective To assess the relationships between plasma and intracellular Ca^2+ , Mg^2+ and blood cell membrane adenosine triphosphatase (ATPase) activity in normotensive and hypertensive subjects. Methods Plasma and intracellular Ca^2+ , Mg^2+ were measured with atomic absorption spectrophotometry, and red blood cell membrane Na^+ K^+ ATPase and Ca 2+ ATPase activities were determined with colorimetric method in 55 patients with essential hypertension and 32 normotensive controls. Results The results showed that the hypertensive group consistently demonstrated a significant decreased activity of ATPase studied, with significantly lower plasma Ca 2+ and higher cytosolic Ca 2+ levels when compared with those in normotensive group (P< 0.01 or P<0.05, respectively). No significant differences were found in either plasma Mg 2+ or intracellular Mg 2+ level between the two groups. Conclusions This study suggests that patients with essential hypertension have widespread depression of cell membrane Na + K + ATPase and Ca 2+ ATPase activities with plasma Ca 2+ depletion and cytosolic Ca 2+ overload, which may reflect an underlying membrane abnormality in essential hypertension. The celluar abnormalities may be related to the defective transport mechanisms that in turn may be aggravated by plasma Ca^2+ depletion.

关键词：云峰 and essential hypertension cell membrane plasma adenosine triphosphatase Erythrocyte Ca

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Association of ITPA polymorphism with outcomes of peginterferon-α plus ribavirin combination therapy

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2013年第3期4卷 54-60页

作者： Tatsuya Fujino Yoko Aoyagi Mariko Takahashi Ryoko Yada Naoko Yamamoto Yuki Ohishi Akihiko Nishiura Motoyuki Kohjima Tsuyoshi Yoshimoto Kunitaka Fukuizumi Manabu Nakashima Masaki Kato Kazuhiro Kotoh Makoto Nakamuta Munechika Enjoji Laboratory for Clinical Investigation National Hospital Organization Nagasaki Medical CenterOhmuraNagasaki 856-8562Japan Clinical Research Institute National Hospital Organization Kyushu Medical CenterFukuoka 814-0180Japan Faculty of Pharmaceutical Sciences Fukuoka UniversityFukuoka 814-0180Japan Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityFukuoka 814-0180Japan

AIM:To analyzed the association between inosine triphosphatase(ITPA)(rs1127354) genotypes and sustained virological response(SVR) rates in peginterferon(Peg-IFN)α + ribavirin(RBV) ***:Patients who underwent Peg-IFNα + RBV combination therapy were enrolled(n = 120) and they had no history of other IFN-based *** in hemoglobin levels during therapy,cumulative reduction of RBV dose,frequency of treatment withdrawal,and SVR rates were investigated in each ITPA ***:In patients with ITPA CC genotype,hemoglobin decline was significantly greater and the percentage of patients in whom total RBV dose was < 60% of standard and/or treatment was withdrawn was significantly higher compared with CA/AA ***,SVR rates were equivalent between CC and CA/AA genotypes,and within a subset of patients with Interleukin 28B(IL28B)(rs8099917) TT genotype,SVR rates tended to be higher in patients with ITPA CC genotype,although the difference was not ***:ITPA CC genotype was a disadvantageous factor for Peg-IFNα + RBV treatment in relation to completion rates and RBV ***,CC genotype was not inferior to CA/AA genotype for SVR *** full-length treatment is accomplished,it is plausible that more SVR is achieved in patients with ITPA CC variant,especially in a background of IL28B TT genotype.

关键词： Chronic hepatitis C Interleukin 28B Inosine triphosphatase Peginterferon Ribavirin

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