Association between polymorphism rs6983267 and gastric cancer risk in Chinese population

作     者：Yi Guo Jing Fang Yan Liu Hai-Hui Sheng Xiao-Yan Zhang Hai-Na Chai Wei jin Ke-Hao Zhang Chang-Qing Yang Heng-jun Gao 

作者机构：DepartmeTo ntngji UniversO ityf GastroenteroloSh gyanghai 200065Tongjc ihinaHospital Affiliated to National EngineeringCenter for Biochip at Shanghai Shanghai 201203 China National Engineering Center for Biochip at Shanghai Shanghai201203 China Department of Cardiology Ruijin HospitalShanghai Jiao Tong University School of Medicine Shanghai200025 China 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2011年第17卷第13期

页      面：1759-1765页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

基　　金：Supported by Shanghai "Phosphor" Science Foundation, China, No. 09QB1403100 the National High Technology Researchand Development Program of China, No. 2006AA020704 and 2006AA02A407 the Funds for Key Programs of Ministry ofHealth of China, No.2008ZX10002-017 

主　　题：Gastric cancer Genetic susceptibility Single nucleotide polymorphism MYC 8q24 

摘      要：AIM: To explore the association between single nucleotide polymorphisms (SNPs) at 8q24 and gastric cancer risk. METHODS: A case-control investigation including 212 gastric cancer patients and 377 healthy controls was conducted. The genotypes of SNPs (rs6983267, rs7008482 and rs10808555) were examined and established through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Multivariate logistic regression models were used to evaluate the association between SNPs and gastric cancer. RESULTS: The genotype frequencies of rs6983267 in gastric cancer patients were obviously different from those in the control (P = 0.005). GT genotype of rs6983267 was associated with an increased risk of gastric cancer compared with GG genotype (adjusted odds ratio = 2.01, 95% confidence interval: 1.28-3.14). Further stratified analysis indicated that rs6983267 GT genotype facilitated the risk of gastric cancer of non-cardiac and intestinal type (OR: 2.638, 95% CI: 1.464-4.753; OR: 1.916, 95% CI: 1.166-3.150, respectively). CONCLUSION: This study demonstrates for the first time that rs6983267 is involved in susceptibility to gastric cancer, although further large-sample investigations are still needed.