Myoelectric activity and motility of the Roux limb after cut or uncut Roux-en-Y gastrojejunostomy

作     者：Ying-Mei Zhang Xiu-Li Liu Dong-Bo Xue Yun-Wei Wei Xiao-Guang Yun 

作者机构：Central Laboratory First Clinical College of Harbin Medical University Harbin 150001 Heilongjiang Province China Department of Oncology First Clinical College of Harbin Medical University Harbin 150001 Heilongjiang Province China Department of General Surgery First Clinical College of Harbin Medical University Harbin 150001 Heilongjiang Province China Department of Pathology Harbin Medical University Harbin 150001 Heilongjiang Province China 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2006年第12卷第47期

页      面：7699-7704页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Roux-en-Y anastomosis Electromyography Gastrointestinal motility c-kit 

摘      要：AIM: To explore the mechanisms of uncut Roux-en-Y gastrojejunostomy, which is used to decrease the occurrence of Roux stasis ***: The changes of myoelectric activity, mechanic motility and interstitial cells of Cajal (ICC) of the Roux limb after cut or uncut Roux-en-Y gastrojejunostomy were observed. RESULTS: When compared with the cut group, the amplitude (1.15 ± 0.15 mV vs 0.48 ± 0.06 mV, P 0.05) and frequency (14.4 ± 1.9 cpm vs 9.5 ± 1.1 cpm, P 0.01) of slow waves and the incidence (98.2% ± 10.4% vs 56.6% ± 6.4%, P 0.05) and amplitude (0.58 ± 0.08 mV vs 0.23 ± 0.06 mV, P 0.01) of spike potential of the Roux limb in the uncut group were significantly higher. The migrating myoelectric complexes (MMC) phase Ⅲ duration in the uncut group was significantly prolonged (6.5 ± 1.1 min vs 4.4 ± 0.8 min, P 0.05), while the MMC cycle obviously shortened (42.5 ± 6.8 vs 55.3 ± 8.2 min, P 0.05). Both gastric emptying rate (65.5% ± 7.9% vs 49.3% ± 6.8%, P 0.01) and intestinal impelling ratio (53.4% ± 7.4% vs 32.2% ± 5.4%, P 0.01) in the uncut group were significantly increased. The contractile force index of the isolated jejunal segment in the uncut group was significantly higher (36.8 ± 5.1 vs 15.3 ± 2.2, P 0.01), and the expression of c-kit mRNA was significantly increased in the uncut group (0.82 ± 0.11 vs 0.35 ± 0.06, P 0.01). CONCLUSION: Uncut Roux-en-Y gastrojejunostomymay lessen the effects of operation on myoelectric activity such as slow waves, spike potential, and MMC, decrease the impairment of gastrointestinal motility, and remarkably increase the expression of c-kit mRNA.