术前血清CA125水平在无盆腔淋巴结转移的早期宫颈腺癌中的价值

作     者：Tsai C.-C. C.-C. ChangChien 李奎 

作者机构：Department of Gynecologic OncologyChangGung Memorial Hospital 123 Ta Pei Road Niao Sung Hsiang Kaohsiung Hsien China 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2006年第2卷第8期

页      面：52-53页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：盆腔淋巴结 宫旁浸润 子宫根治术 间质浸润 组织病理学 淋巴结阴性 多因素分析 界值 

摘      要：Objective. This investigation attempted to clarify the value of preoperative serum CA125 in predicting histopathological prognostic factors for early-stage cervical adenocarcinoma without lymph node metastasis. Methods. This study initially surveyed 163 patients with clinical stage Ib or IIa cervical adenocarcinoma treated with radical hysterectomy and pelvic lymphadenectomy. Of the 163 patients, 116 had preoperative serum CA125 levels, and 14 had pelvic lymph node metastasis. The investigation group comprised 102 lymph node-negative patients. Results. A cutoff value of 26 U/ml was obtained after the discriminant function analysis for identifying patients with positive lymph vascular space invasion (LVSI) or depth of stromal invasion ≥ 2/3 thickness. Multivariate analysis revealed that among the preoperative clinicopathological variables, including age, tumor size, parametrial invasion, and CA125 level, raised CA125 most significantly influenced the assessment of the LVSI (P = 0.040) and depth of cervical stromal invasion (P = 0.002). Conclusions. In early-stage cervical adenocarcinoma with negative pelvic lymph node metastasis, preoperative serum CA125 levels at the cutoff value of 26 U/ml impacted the determination of the poor histopatho-logical prognostic factors.