Chiral Schiff Base Ligands Containing Ferrocene and Pyridine Units for Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation

作     者：DAI Huicong, HU Xiangping, CHEN Huilin, BAI Changmin, ZHENG Zhuo (Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, Liaoning, China) DAI Huicong;HU Xiangping;Chen Huilin;BAI Changmin;ZHENG Zhuo

作者机构：Dalian Institute of Chemical Physics The Chinese Academy of Sciences 辽宁 Dalian 116023 

出 版 物：《催化学报》 (Chin. J. Catal.)

年 卷 期：2003年第24卷第8期

页      面：565-566页

核心收录：

学科分类：081705[工学-工业催化] 08[工学] 0817[工学-化学工程与技术] 

基　　金：theNationalNaturalScienceFoundationofChina (2 99330 5 0 ) 

主　　题：钌催化剂 不对称转移 氢化作用 手性席夫碱配位化合物 二茂铁 嘧啶单体 

摘      要：Chiral Schiff base complexes are very efficient for a wide range of reactions, including expoxidation, epoxide ring opening, Diels-Alder reaction, aldol reaction, etc. However, there are only few examples of P-N chelate Schiff bases being used as the chiral ligands in the asymmetric transfer hydrogenation of ketones. Recently, Gao et al reported a series of P,N,N,P Schiff base ligands that have relatively low ennatioselectivity in the asymmetric transfer hydrogenation of ketones. Here, we report the synthesis of a series of new P,N,N Schiff base ligands 4 (4a, 4b and 4c) and their application in the ruthenium-catalyzed asymmetric transfer hydrogenation. Up to 90% enantiomeric excess (ee) was obtained in the transfer hydrogenation of ethyl phenyl ketone using Ru(DMSO)_4Cl_2/4c as catalyst.