Silica-supported Thionyl Chloride-assisted Synthesis and Bioassay of Novel Tetrazinan-3-thione and 3-Oxo-pyrazolidine-4-carbonitrile Derivatives of Steroids

作     者：PARVEEN Mehtabl MALLA Ali Mohammed ALl Akhtar ALAM Mahboob MUSTAFA Mir Faisal 

作者机构：Department of ChemistryAligarh Muslim University Aligarh 202002 India Department of Biochemistry Aligarh Muslim University Aligarh 202002 India 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2014年第30卷第1期

页      面：55-62页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：Council of Scientific and Industrial Research, India, CSIR University Grants Committee, UGC Aligarh Muslim University, AMU 

主　　题：Steroid Biological evaluation Molecular docking 

摘      要：A series of tetrazinan-3-thione and 3-oxo-pyrazolidine-4-carbonitrile derivatives of steroids（1-3） were synthesized with silica-chloride as a heterogeneous *** synthesized compounds 4-9 were obtained in substantial *** vitro evaluation of anticancer and antioxidant activity of the synthesized compounds was carried out via 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide（MTT） and 1,1-diphenyl-2-picrylhydrazyl（DPPH）assays,*** 6 exhibited promising anti-proliferative activity towards a panel of cancer cell *** significant activity of compound 6 was further ascertained on structural,molecular modelling and docking *** study may provide a valuable insight into the further design and development of more potent biologically active compounds.