Investigating the potential of essential oils as penetration enhancer for transdermal losartan delivery: Effectiveness and mechanism of action
作者机构：Department of PharmaceuticsFaculty of PharmacyHamdard UniversityNew Delhi 110062India Department of PharmaceuticsCollege of PharmacyKing Saud UniversityP.O.Box 2457Riyadh 11451Saudi Arabia Quality Assurance UnitFortis Clinical Research LtdNew DelhiIndia
出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)
年 卷 期：2014年第9卷第5期
页 面：260-267页
学科分类：081803[工学-地质工程] 08[工学] 0818[工学-地质资源与地质工程]
主 题：Aloe vera oil Essential oils Losartan Skin permeation Transdermal
摘 要：The effect of tea tree oil(TTO),cumin oil(CO),rose oil(RO)and aloe vera oil(AVO)on the skin permeation of losartan potassium(LP)was *** vitro skin permeation studies were carried out using rat *** mechanism of skin permeation enhancement of LP by essential oils treatment was evaluated by FTIR,DSC,activation energy measurement and histopathological *** concurrent ethanol/enhancer treatment and neat enhancer pretreatment of rat SC with all the oils produced significance increase in the LP flux over the *** effectiveness of the oils as the penetration enhancers was found to be in the following descending order:AVOROCO***,only AVO was the only enhancer to provide target flux required to deliver the therapeutic transdermal dose of *** and DSC spectra of the enhancer treated SC indicated that TTO,CO,RO and AVO increased the LP permeation by extraction of SC *** results of thermodynamic studies and histopathological examination of AVO treated SC suggested additional mechanisms for AVO facilitated permeation *** reduction in barrier resistance of SC and intracellular transport by dekeratinization of corneocytes which may be attributed to the presence of triglycerides as constituents of *** is feasible to deliver therapeutically effective dose of LP via transdermal route using AVO as penetration enhancer.
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