Controversies regarding and perspectives on clinical utility of biomarkers in hepatocellular carcinoma
Controversies regarding and perspectives on clinical utility of biomarkers in hepatocellular carcinoma作者机构：Hepato-Biliary-Pancreatic Surgery DivisionDepartment of SurgeryGraduate School of Medicinethe University of Tokyo
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2016年第22卷第1期
页 面：262-274页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by Grants-in-Aid from the Ministry of Education Science Sports and Culture of Japan
主 题：Hepatocellular carcinoma Biomarker Guideline Surveillance Diagnosis Prognosis
摘 要：The prevalence of hepatocellular carcinoma(HCC)worldwide parallels that of persistent infection with the hepatitis B virus(HBV)and/or hepatitis C virus(HCV).According to recommendations by the World Health Organization guidelines for HBV/HCV,alpha-fetoprotein(AFP)testing and abdominal ultrasound should be performed in routine surveillance of HCC every 6 mo for high-risk *** examinations have also been recommended worldwide by many other HCC guidelines over the past few *** recent years,however,the role of AFP in HCC surveillance and diagnosis has diminished due to advances in imaging *** was excluded from the surveillance and/or diagnostic criteria in the HCC guidelines published by the American Association for the Study of Liver Diseases in 2010,the European Association for the Study of the Liver in 2012,and the National Comprehensive Cancer Network in *** biomarkers,including the Lens culinaris agglutinin-reactive fraction of AFP(AFP-L3),des-γ-carboxyprothrombin,Dickkopf-1,midkine,and micro RNA,are being studied in this ***,increasing attention has focused on the clinical utility of biomarkers as pre-treatment predictors for tumor recurrence and as post-treatment *** and tissue-based biomarkers and genomics may aid in the diagnosis of HCC,determination of patient prognosis,and selection of appropriate ***,further studies are needed to better characterize the accuracy and potential role of these approaches in clinical practice.
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