Aspirin combined with mechanical measures to prevent venous thromboembolism after total knee arthroplasty： a randomized controlled trial
Aspirin combined with mechanical measures to prevent venous thromboembolism after total knee arthroplasty： a randomized controlled trial作者机构：Department of Joint Reconstructive SurgeryBeijing Jishuitan HospitalBeijing 100035China
出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)
年 卷 期：2014年第127卷第12期
页 面：2201-2205页
核心收录：
学科分类：0821[工学-纺织科学与工程] 0907[农学-林学] 08[工学] 0829[工学-林业工程] 09[农学] 082101[工学-纺织工程]
主 题：aspirin venous thromboembolism prevention arthroplasty replacement knee
摘 要：Background Venous thromboembolism （VTE） is an important complication after major orthopedic *** methods represent the main strategy of VTE *** use of aspirin in VTE prevention is still controversial worldwide,especially in *** purpose of this study was to evaluate the role of aspirin combined with mechanical measures in the prevention of VTE after total knee arthroplasty （TKA）.Methods Between January 2012 and May 2013 and in accordance with the inclusion criteria,120 patients undergoing TKA were randomly allocated to two *** prevent VTE,patients in group A received aspirin combined with mechanical measures postoperatively,while patients in group B received low-molecular-weight heparin （LMWH） sodium and rivaroxaban sequentially in combination with mechanical measures *** surgeries were performed by one surgeon using a posterior-stabilized cemented *** two groups were followed up and compared for the incidence of deep vein thrombosis （DVT） by duplex ultrasound scan and clinical VTE *** adverse events,the blood loss index,and the cost of VTE prevention were also *** DVT was detected in 10 of 60 patients in group A （16.7％,95％ CI：7.3％-26.1％） compared with 11 of 60 in group B （18.3％,95％ CI：8.5％-27.8％） （P=0.500）.There is no statistical evidence supporting the inferior effect of aspirin in preventing DVT as compared with the other *** were no cases of symptomatic VTE or death during the follow-up *** of ecchymosis was lower in group A than in group B,and the differences were statistically *** in group A had the lower blood loss index as compared with patients in group *** transfusion cases were found in both *** differences were statistically *** cost of VTE prevention analysis indicated a cost reduction using aspirin in group A compared with using LMWH and rivaroxaban in group *** Aspirin combined with mechanical measu
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