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Optimizing bone marrow harvesting sites for enhanced mesenchymal stem cell yield and efficacy in knee osteoarthritis treatment

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World Journal of Methodology 2025年第2期15卷 92-107页

作者： Arulkumar Nallakumarasamy Sandeep Shrivastava Ravi Velamoor Rangarajan Naveen Jeyaraman Avinash Gandi Devadas Swaminathan Ramasubramanian Madhan Jeyaraman Department of Orthopaedics Datta Meghe Institute of Higher Education and ResearchWardha 442004MaharashtraIndia Department of Regenerative Medicine Mother Cell Regenerative CentreTiruchirappalli 620017Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia

knee osteoarthritis(OA)is a debilitating condition with limited long-term treatment *** therapeutic potential of mesenchymal stem cells(MSCs),particularly those derived from bone marrow aspirate concentrate,has garnered attention for cartilage repair in *** the iliac crest is the traditional site for bone marrow harvesting(BMH),associated morbidity has prompted the exploration of alternative sites such as the proximal tibia,distal femur,and proximal *** paper reviews the impact of different harvesting sites on mesenchymal stem cell(MSC)yield,viability,and regenerative potential,emphasizing their relevance in knee OA *** iliac crest consistently offers the highest MSC yield,but alternative sites within the surgical field of knee procedures offer comparable MSC characteristics with reduced *** integration of harvesting techniques into existing knee surgeries,such as total knee arthroplasty,provides a less invasive approach while maintaining thera-peutic ***,variability in MSC yield from these alternative sites underscores the need for further research to standardize techniques and optimize clinical *** directions include large-scale comparative studies,advanced characterization of MSCs,and the development of personalized harvesting ***,the findings suggest that optimizing the site of BMH can significantly influence the quality of MSC-based therapies for knee OA,enhancing their clinical utility and patient outcomes.

关键词： knee Osteoarthritis Mesenchymal stem cells Bone marrow harvest Regenerative medicine

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Current status of nanofat in the management of knee osteoarthritis:A systematic review

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World Journal of Orthopedics 2025年第1期16卷 68-78页

作者： Naveen Jeyaraman Sandeep Shrivastava VR Ravi Arulkumar Nallakumarasamy Madhan Jeyaraman Department of Orthopaedics Datta Meghe Institute of Higher Education and ResearchWardha 442004MaharashtraIndia Department of Regenerative Medicine Mother Cell Regenerative CentreTiruchirappalli 620017Tamil NaduIndia Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia

BACKGROUND Osteoarthritis(OA)is a prevalent joint disorder requiring innovative treatment *** To evaluate the use of nanofat,a specialized form of adipose tissue-derived cells,in the treatment of OA,by examining its efficacy,safety profile,mechanisms of action,comparative effectiveness,and long-term *** A comprehensive review of preclinical studies,clinical trials,and in vitro investigations was *** included studies provided insights into the potential role of nanofat in OA treatment,addressing its efficacy,safety profile,mechanisms of action,comparative effectiveness,and long-term *** Clinical studies consistently reported the efficacy of nanofat in providing pain relief and functional improvement in patients with *** adverse events were limited to the injection site,such as localized pain and inflammation,and resolved within a few days to *** adverse events were rare,and no significant long-term complications were ***,nanofat was found to enhance chondrocyte proliferation,reduce inflammation,and promote angiogenesis,thereby contributing to its therapeutic *** Nanofat therapy holds promise as a therapeutic option for managing OA,providing pain relief,functional improvement,and potential tissue *** safety profile of nanofat treatment appears favorable,but long-term data are still *** protocols,larger randomized controlled trials,longer follow-up periods,and cost-effectiveness evaluations are warranted to establish optimal protocols,comparative effectiveness,and long-term *** current limitations,nanofat therapy demonstrates translational potential and should be considered in clinical practice for OA treatment,with careful patient selection and monitoring.

关键词： Osteoarthritis Nanofat Adipose tissue Cartilage knee

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Analysis of the Biotribological Behavior for the Stainless Steel/Polyethylene Contact Using a knee Prosthesis Simulator

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Journal of Bionic Engineering 2012年第1期9卷 59-65页

作者： M. Boujelbene S. Dhouibi M. Kharrat M. Dammak Laboratoire des Systkmes Electromeeaniques Ecole Nationale d＇Ingenieurs de Sfax Route de Soukra km 35 B.P. 1173 3038 Sfax Tunisia Institut Superieur de Gestion Industrielle de Sfax Route de Mharza Km 15 B.P. 954 3018 Sfax Tunisia Faeulte des Sciences de Gafsa Campus Universitaire Sidi Ahmed Zarrouk 2112 Gafsa Tunisia Institut Preparatoire aux Etudes d＇Ingenieurs de Sfax Route de Menzel Chaker Km 05 B.P. 1172 3018 Sfax Tunisia

In this work, a friction and wear simulator was used to reproduce the Anterior-Posterior （AP） sliding and the Flex- ion-Extension （FE） rotation generated in the knee joint during human gait cycle. We chose to simplify the contact geometry between the Total knee Arthroplasty （TKA） femoral component and tibial insert. A 304L stainless steel cylinder which replaces the femoral component was loaded onto a flat High Density Polyethylene （HDPE） block which replaces the tibial insert. The tribological behavior of the considered contact was analyzed by tracking the number of cycles, the friction coefficient, the roughness of the wear track on HDPE, the HDPE weight loss and the damage mechanisms. The friction coefficient shows a gradual increase with the number of cycles for both AP and FE kinematics. The evolution of friction coefficient with the number of cycles is not affected by the value of the imposed normal load in the case of AP sliding. For the FE rotation, decreased friction coefficient is obtained when the imposed normal load increases. For both considered AP and FE kinematics, the roughness of the wear track on the HDPE is not affected by the imposed normal load. It shows a progressive decrease when the number of cycles increases. The wear of HDPE obeys the Archard law and the wear coefficient increases with the normal force. For a given value of normal load, the obtained wear coefficient for the AP sliding is larger than that obtained for FE rotation. A predominant adhesive wear mechanism was identified for both AP and FE kinematics. Under the same normal load, damage development in terms of plastic deformation, micro-cracking and debonding is more pronounced for the AP sliding if compared with the FE rotation. For a given kinematics, the damage severity increases with the normal load. This finding is in good agreement with the predicted values of the wear coefficient according to the Archard law.

关键词： knee prosthesis polyethylene friction wear gait cycle

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Static and Dynamic Analysis of Osteoarthritic and Orthotic Human knee

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Journal of Bionic Engineering 2019年第3期16卷 514-525页

作者： Daniela Tarnita Doina Pisla Ionut Geonea Calin Vaida Marius Catana Danut Nicolae Tarnita University of Craiova Faculty of Mechanics Calea Bucuresti no. 107 200512 Craiova Romania Technical University Cluj Napoca CESTER - Research Centre for the Robot Simulation and Testing Memorandumului str. no. 28400114 Cluj-Napoca Romania INAS Nicolae Romanescu Blvd 37C 200738 Craiova Romania University of Medicine and Pharmacy Craiova & Emergency Hospital Craiova Craiova Petru Rares str. no. 2 200349 Romania

The first objective of this paper is to study the influence of the orthotic device on the maximum values of stresses in knee cartilages by using Ansys Workbench 14.5 software and applying the Finite Element Analysis (FEA) on a virtual assembly composed by an orthotic device and osteoarthritic knee (OAK). The second objective consists into quantifying and investigating the nonlinear motion of the human knee joint for OAK patients, with and without the orthotic device mounted on OAK, using tools of dynamics stability analysis. The short Lyapunov Exponents (LEs) are calculated, as measures of human knee and ankle joints stability, based on the experimental time series collected by using the biometrics acquisition system during walking on horizontal and inclined treadmills from a sample of healthy subjects and a sample of patients suffering by OAK disease. The values of LEs obtained for OAK patients are larger on the inclined treadmill than on horizontal treadmill and are larger than those obtained for healthy knees, being associated with more divergence and less stability. The results confirm that the influence of an orthotic device mounted on OAK on its stability is significant, the values obtained for LEs being smaller than those calculated for OAK, and closer to the values of normal knees of patients and of healthy subjects.

关键词： osteoarthritic knee bioinspired orthosis finite element method gait stability Lyapunov exponents

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On the knee of Galactic cosmic rays in light of sub-TeV spectral hardenings

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Chinese Physics C 2018年第7期42卷 113-122页

作者： Yi-Qing Guo1 2 Qiang Yuan1 3 1. Key Laboratory of Dark Matter and Space Astronomy Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210008 China 2. Key Laboratory of Particle Astrophysics Institute of High Energy Physics Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of Sciences Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences School of Astronomy and Space Science University of Science and Technology of China

More than fifty years after the discovery of the knee in the cosmic ray （CR） spectra, its physical origin remains a mystery. This is partly due to the ambiguity of the energy spectra of individual components. Recently, direct measurements from several space experiments found significant spectral hardenings of CR nuclei at ~200 GV. A joint modeling of the direct and indirect measurements may help to understand the experimental systematics and the physics of the knee. In this work, we update the phenomenological ＂poly-gonato＂ model to include the spectral hardenings, with a changing spectral index of γ ＋ β·logE. This modification gives a reasonable description of the CR spectra in a wide energy range. However, the fits to different data sets give different results. We find that the fit to the AMS-02 and CREAM data slightly favors a relatively low energy knee of the light components. In such a case, the expected all-particle spectra under-shoot the data, which may require an extra component of CRs. The fits to AMS-02 data and the light component （H＋He） data from the Tibet ASγ/ARGO-YBJ/WFCTA and KASCADE experiments give consistent results with the all-particle spectra. We further propose a possible physical realization of such a ＂modified poly-gonato＂ model of spectral hardenings by means of spatially-dependent diffusion of CRs. We find reasonably good agreement between the model predictions and the data for CR spectra, the secondary-to-primary ratios, and the amplitude of anisotropies.

关键词： cosmic ray knee spectrum propagation

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Classification of four distinct osteoarthritis subtypes with a knee joint tissue transcriptome atlas

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Bone Research 2020年第4期8卷 406-415页

作者： Chunhui Yuan Zongyou Pan Kun Zhao Jun Li Zixuan Sheng Xudong Yao Hua Liu Xiaolei Zhang Yang Yang Dongsheng Yu Yu Zhang Yuzi Xu Zhi-Yong Zhang Tianlong Huang Wanlu Liu Hongwei Ouyang Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cells and Regenerative Medicine and Department of Orthopedic Surgery of the Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Zhejiang University-University of Edinburgh Institute Zhejiang University School of Medicineand Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang ProvinceZhejiang University School of MedicineHangzhouChina Department of Sports Medicine Zhejiang University School of MedicineHangzhouChina Department of Orthopedics The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouChina China Orthopedic Regenerative Medicine Group(CORMed) HangzhouChina Department of Orthopedics Zhejiang Provincial People’s HospitalHangzhou Medical CollegeHangzhouChina Translational Research Centre of Regenerative Medicine and 3D Printing Technologies of Guangzhou Medical University State Key Laboratory of Respiratory DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina The Second Xiangya Hospital of Central South University ChangshaChina

The limited molecular classifications and disease signatures of osteoarthritis(OA)impede the development of prediagnosis and targeted therapeutics for OA *** classify and understand the subtypes of OA,we collected three types of tissue including cartilage,subchondral bone,and synovium from multiple clinical centers and constructed an extensive transcriptome atlas of OA *** applying unsupervised clustering analysis to the cartilage transcriptome,OA patients were classified into four subtypes with distinct molecular signatures:a glycosaminoglycan metabolic disorder subtype(C1),a collagen metabolic disorder subtype(C2),an activated sensory neuron subtype(C3),and an inflammation subtype(C4).Through ligand-receptor crosstalk analysis of the three knee tissue types,we linked molecular functions with the clinical symptoms of different OA *** example,the Gene Ontology functional term of vasculature development was enriched in the subchondral bone-cartilage crosstalk of C2 and the cartilage-subchondral bone crosstalk of C4,which might lead to severe osteophytes in C2 patients and apparent joint space narrowing in C4 *** on the marker genes of the four OA subtypes identified in this study,we modeled OA subtypes with two independent published RNA-seq datasets through random forest *** findings of this work contradicted traditional OA diagnosis by medical imaging and revealed distinct molecular subtypes in knee OA patients,which may allow for precise diagnosis and treatment of OA.

关键词： diagnosis subtypes knee

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A study on the sharp knee and fine structures of cosmic ray spectra

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Science China(Physics,Mechanics & Astronomy) 2010年第5期53卷 842-847页

作者： WANG Bo1,YUAN Qiang1,FAN Chao1,2,ZHANG JianLi1,HU HongBo1 & BI XiaoJun1 1 Key Laboratory of Particle Astrophysics,Institute of High Energy Physics,Chinese Academy of Sciences,Beijing 100049,China 2 Department of Physics,Shandong University,Jinan 250100,China 1. Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China2. Department of Physics Shandong University Jinan 250100 China

The paper investigates the overall and detailed features of cosmic ray(CR) spectra in the knee region using the scenario of nuclei-photon interactions around the acceleration *** supernova remnants can be the physical realities of such kind of CR acceleration *** results show that the model can well explain the following problems simultaneously with one set of source parameters:the knee of CR spectra and the sharpness of the knee,the detailed irregular structures of CR spectra,the so-called"component B"of Galactic CRs,and the electron/positron excesses reported by recent *** coherent explanation serves as evidence that at least a portion of CRs might be accelerated at the sources similar to young supernova remnants,and one set of source parameters indicates that this portion mainly comes from standard sources or from a single source.

关键词： cosmic ray knee fine structures e+e-excesses "component B" single source

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Effect of manipulation on cartilage in rats with knee osteoarthritis based on the Rho-associated protein kinase/LIM kinase 1/Cofilin signaling pathways

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Journal of Traditional Chinese Medicine 2022年第2期42卷 194-199页

作者： GUO Xiao YANG Yunhao LIAO Dongmei PANG Fang YANG Zhixue ZHU Zhengwei LUO Ao TANG Chenglin College of Traditional Chinese Medicine Chongqing Medical UniversityChongqing 400010China Beibei Traditional Chinese Medicine Hospital Chongqing 400700China

OBJECTIVE:To investigate the effect of manipulation treatment on knee osteoarthritis rats and the effect on Rho-associated protein kinase(ROCK)/LIM-kinase1(LIMK1)/Cofilin signaling ***:Fifty Specific pathogen Free Sprague-Dawley rats were randomly divided into five groups(n=8 each):blank group,model group,manipulation group,celecoxib group,and manipulation combined with celecoxib group(MC group).The osteoarthritis model was established by injecting 0.2 m L 4%papain into the articular disc of the *** successfully establishing the model,we treated the manipulation group with pushing manipulation using one-finger-meditation to the Neixiyan(EX-LE4),Waixiyan(EX-LE5),Xuehai(SP10),Liangqiu(ST34),and Zusanli(ST36)acupoints for 10 min each ***,the celecoxib group was gavaged with 24 mg·kg^(-1)·d^(-1 )celecoxib,while the MC group was treated using both of these two *** four weeks,the cartilage of the right femur was removed for hematoxylin-eosin staining of the cartilage *** expressions of interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)in serum were observed using the enzyme-linked immunosorbent ***,we detected the expressions of ROCK,LIMK1,Phospho-LIM-kinase1(Phospho-LIMK1),Cofilin,and Phospho-Cofilin by Western ***:Compared to the model group,the manipulation group,celecoxib group,and MC group all exhibited superior results concerning pathological morphologic changes of cartilage,as observed by hematoxylin-eosin staining and calculated using the Mankin ***,in contrast to the blank group,the model group exhibited elevated serum levels of IL-1βand TNF-α(P<0.01),while the expression of ROCK,LIMK1,Phospho-LIMK1,Cofilin,and Phospho-Cofilin in cartilage were all higher(P<0.01).Also,the serum levels of IL-1βand TNF-αin each treatment group were lower(P<0.01)than in the model ***,there were lower expressions of ROCK,LIMK1,Phospho-LIMK1,Cofilin,and Phospho-Cofilin in cartilage in the manipulatio

关键词： osteoarthritis knee manipulation cytoskeletal proteins Rho-associated kinases LIM kinases actin depolymerizing factors signal transduction

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Protocol to establish auxiliary diagnostic model for knee osteoarthritis functional testing equipment

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Journal of Traditional Chinese Medicine 2023年第2期43卷 379-385页

作者： GUO Zhuang WANG Junwen LI Zhonglong CHEN Zhongjie CHEN Li YAN Shiyan LU Hongrong LI Zhigeng LI Guanying Institute of Basic Theory of Chinese Medicine China Academy of Chinese Medical ScienceBeijing 100700China Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100700China Department of Acupuncture Moxibustion and MassageBeijing HospitalBeijing 100000China Department of Acupuncture Moxibustion and MassageWuhan Hongshan Chinese Medicine HospitalHubei 430070China School of Humanities Beijing University of Chinese MedicineBeijing 100029China

In China,50%of knee Osteoarthritis(KOA)patients will be treated with Traditional Chinese Medicine or a combination of Traditional Chinese and Western Medicine,which call for objective efficacy evaluation *** collection,processing and fusion of multisource data were taken as the main methods,with 150 KOA patients and 100 healthy people as an example to design prospective clinical *** were collected with tongue inspection APP,infrared instrument and channel instrument,*** the analysis,screening,fusion and modelling of multi-source data were *** traditional clinical tests have been combined with the customized information platform in this study,which is convenient for clinical tests,medical follow-ups and timely feedback to statistical analysis of data.

关键词： osteoarthritis knee multi-source data efficacy evaluation prospective clinical test diagnostic tests routine protocol

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Effect of Taijiquan practice versus wellness education on knee pro-prioception in patients with knee osteoarthritis:a randomized con-trolled trial

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Journal of Traditional Chinese Medicine 2017年第6期37卷 774-781页

作者： Zhu Qingguang Huang Lingyan Li Jingxian Mao Lijuan Zhang Yunya Min Fang Yu Liu Department of Physical Therapy with Chinese Massage Yueyang Hospital of Integrated TraditionalChinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437ChinaKey Laboratory of Exercise and Health SciencesMinistry of Educa-tionShanghai University of SportShanghai 200438China Key Laboratory of Exercise and Health Sciences Ministry of EducationShanghai University of SportShanghai 200438China Key Laboratory of Exercise and Health Sciences Ministry of EducationShanghai University of SportShanghai 200438ChinaSchool of Human KineticsFaculty of Health SciencesUniversity of OttawaOttawa KIN 6N5Canada

OBJECTIVE: To determine the effects of Taijiquan practice on knee proprioception in patients with knee osteoarthritis(OA).METHODS: We conducted a randomized controlled trial comparing Taijiquan with a control condition(wellness education) in patients with knee OA. The patients participated in either a 60-min Taijiquan session three times weekly or a 60-min weekly educational session, for 24 consecutive weeks. The primary outcomes were changes in knee proprioception. Secondary outcomes were changes in the Western Ontario and Mc Master University Osteoarthritis Index(WOMAC).RESULTS: After 24 weeks, compared with the control group, the Taijiquan group demonstrated better improvements in the joint position sense in knee flexion(left:-2.12°; right:-2.02°), and knee extension(left:-2.22°; right:-1.54°). In addition,the Taijiquan group showed significantly greater improvements in the WOMAC scores(P knee pain(left:-3.17 points; right:-3.74 points),stiffness(left:-2.43 points; right:-2.13 points),and physical function(left:-10.99 points; right:-8.00 points), compared with the control ***: A 24-week Taijiquan practice resulted in a significant improvement in knee proprioception in patients with knee OA. The present findings add increasing evidence regarding the clinical benefits of Taijiquan as a therapeutic modality for patients to improve the reflex protection of knee joints against potentially harmful forces.

关键词： Tai ji Osteoarthritis, knee Rheumaticdiseases Pain Proprioception Randomized con-trolled trial

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