Reactive oxygen species and antioxidants relationship in the internal spermatic vein blood of infertile men with varicocele

作     者：TaymourMostafa TarekH.Anis SherifGhazi AbdelRahmanEl-Nashar Hager Imam Ihab A.Osman 

作者机构：Andrology DepartmentFaculty of MedicineCairo UniversityCairo 12311Egypt Medical Biochemistry DepartmentOphthalmology Institute GizaEgypt 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2006年第8卷第4期

页      面：451-454,516页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：varicocele spermatic vein reactive oxygen species antioxidants 

摘      要：Aim:To assess the relation of reactive oxygen species(ROS)and antioxidants in the internal spermatic vein blood compared to the peripheral venous ***:Sixty-eight infertile oligoasthenozoospemic patients associated with varicocele were *** inguinal varicocelectomy,blood samples of internal sper- matic as well as median cubital veins were *** ROS factors(malondialdehyde[MDA],hydrogen peroxide H_2O_2,nitric oxide[NO])and four antioxidants(superoxide dismutase[SOD],catalase[Cat],glutathione peroxidase[GPx] and vitamin C)were estimated in these blood ***:Mean levels of tested ROS factors were significantly higher in the internal spermatic venous blood compared to those in the peripheral one (mean±SD)(MDA 18.7±1.4 nmol/mL vs.15.4±1.4 nmol/mL,H_2O_2 43.6±8.0 μmol/mL vs.30.8±8.1 μmol/mL,NO 2.3±0.5 nmol/L vs.1.6±0.4 nmol/L,P0.01).Mean levels of tested antioxidants were significantly lower in the internal spermatic venous blood compared to those in the peripheral one(superoxide dismutase 1690.7±130.0 U/mL vs.1818.5±143.0 U/mL,catalase 38.9±6.1 mol/L vs.47.9±10.2 mol/L,GPx 20.4±8.1 U/mL vs.23.0±8.4 U/mL,vita- min C 0.3±0.1 vs.0.4±0.1 mg/dL,P0.05).Conclusion:Internal spermatic venous blood of infertile male cases associated with varicocele demonstrated elevated levels of ROS and decreased levels of antioxidants compared to peripheral venous circulation.(Asian J Androl 2006 Jul;8:451-454)