Down-regulated expression of NPM1 in IMS-M2 cell line by(-)-epigallocatechin-3-gallate

作     者：Hoang Thanh Chi Bui Thi Kim Ly Hoang Anh Vu Yuko Sato Phu Chi Dung Phan Thi Xinh 

作者机构：Department of Molecular CytogeneticsHematology and Blood Transfusion Hospital in Ho Chi Minh City Department of Medical Genome SciencesGraduate School of Frontier Sciencesthe University of Tokyo Center for Molecular Biomedicine.The University of Medicine and Pharmacy-Ho Chi Minh City Basic nursing scienceThe Japanese Red Cross College of Nursing Japan 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2014年第4卷第7期

页      面：570-574页

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by the Japan Foundation for Promotion of International Medical Research Co-operation(JF-PIMRC) 

主　　题：NPM1 EGCG IMS-M2 Apoptosis 

摘      要：Objective:To investigate the inhibited effect of epigallocatechin-3-gallate(EGCG)on the expression of NPM1 in IMS-M2 cells harboring the NPMl ***:Cell proliferation assay was performed to test the effects of EGCG on eell growth of IMS-M2 cells harboring the NPM1 *** blot analysis were performed to test the protein expression of NPM1,AKT,those associated with ***:EGCG can down-regulate the expression of NPM1 in IMS-M2 cells harboring the ***,EGCG also suppressed the cell proliferation and induced apoptosis in IMSM2 ***:The results suggested that EGCG could be considered as a reagent for treatment of AML patients with NPM1 mutations.