Growth effects of botulinum toxin type A injected unilaterally into the masseter muscle of developing rats

作     者：Chanyoung PARK Kitae PARK Jiyeon KIM 

作者机构：Department of Pediatric Dentistry Institute of Oral Health Science Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 135-710 Korea Department of Pediatric Dentistry School of Dentistry Dental Research Institute Pusan National UniversityYangsan 626-870 Korea 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2015年第16卷第1期

页      面：46-51页

核心收录：

学科分类：1003[医学-口腔医学] 100302[医学-口腔临床医学] 10[医学] 

基　　金：supported by the Samsung Biomedical Research Institute Grant(No.CA53061) Korea 

主　　题：Botulinum toxin Craniofacial growth Mandible 

摘      要：Objective： To evaluate the effects of botulinum toxin type A （BTX-A） on mandible skeletal development by inducing muscle hypofunction. Methods： Four-week-old Sprague-Dawley rats （n=60） were divided into three groups： Group 1 animals served as controls and were injected with saline; Group 2 animals were injected unilaterally with BTX-A （the contralateral side was injected with saline）; and Group 3 animals were injected bilaterally with BTX-A. In Group 2, the saline-injected side was designated the control side （Group 2-1）, whereas the BTX-A-injected side was designated the experimental side （Group 2-2）. After four weeks, the animals were sacrificed, dry skulls were prepared, and mandibles were measured. Results： In the unilateral group, the experimental side （Group 2-2） had reduced di- mensions for all mandible measurements compared with the control side （Group 2-1）, suggesting a local effect of BTX-A on mandible growth, likely due to muscle reduction. Conclusions： Localized BTX-A injection induced a change in craniofacial growth, and the skeletal effect was unilateral despite both sides of the mandible functioning as one unit.