Effect of degradation of PLGA and PLGA/β-TCP scaffolds on the growth of osteoblasts

作     者：YANG YanFang TANG GongWen ZHAO YunHui ZHANG Yang LI XiuLan YUAN XiaoYan 

作者机构：School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Tianjin University Tianjin 300072 China Institute of Orthopedics Tianjin Hospital Tianjin 300211 China 

出 版 物：《Chinese Science Bulletin》 (中国科学通报)

年 卷 期：2011年第56卷第10期

页      面：982-986页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：supported by the National Natural Science Foundation of China(10672015 and 30828008) 

主　　题：PLGA 多孔支架 成骨细胞 细胞生长 TCP 退化 细胞相容性 生物相容性 

摘      要：Osteoblasts were cultured on porous scaffolds of poly(L-lactide-co-glycolide) (PLGA) and PLGA/β-tricalcium phosphate (β-TCP) to evaluate their *** proliferation of the cells on both scaffolds was examined before and after in vitro degradation for 4,8 and 12 weeks under static (shaking water bath) and dynamic (cyclic loading) *** indicate that porous PLGA and PLGA/β-TCP scaffolds have good biocompatibility and can be used as effective templates for guiding the growth of *** degradation of the scaffolds affects the proliferation of osteoblasts and the cell viability decreased with the degradation time.