Impact of bolus volume on small intestinal intra-luminal impedance in healthy subjects

作     者：Nam Q Nguyen Laura K Bryant Carly M Burgstad Robert J Fraser Daniel Sifrim Richard H Holloway 

作者机构：Department of Gastroenterology & HepatologyRoyal Adelaide HospitalAdelaide 5000Australia Investigation and Procedures UnitRepatriation General HospitalDaw Park 5041Australia Department of MedicineCentre for Gastroen-terological ResearchK.U.LeuvenLeuven 3000Belgium 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2010年第16卷第17期

页      面：2151-2157页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by The National Health and Medical Research Council of Australia 

主　　题：Bolus volume Health Impedance Luminal flow Small intestine 

摘      要：AIM: To assess the impact of bolus volume on the characteristics of small intestinal (SI) impedance ***: Concurrent SI manometry-impedance measurements were performed on 12 healthy volunteers to assess the pattern of proximal jejunal fluid bolus movement over a 14 *** subject was given 34 boluses of normal saline (volume from 1 to 30 mL) via the feeding tube placed immediately above the proximal margin of the studied segment.A bolus-induced impedance event occurred if there was 12% impedance drop from baseline,over ≥ 3 consecutive segments within 10 s of bolus injection.A minor or major imped-ance event was defined as a duration of impedance drop 60 s or ≥ 60 s,***: The minimum volume required for a detectable SI impedance event was 2 mL.A direct linear relationship between the SI bolus volume and the occurrence of impedance events was noted until SI bolus volume reached 10 mL,a volume which always produced an impedance flow *** was a moderate correlation between the bolus volume and the duration of impedance drop (r = 0.63,P 0.0001) and the number of propagated channels (r = 0.50,P 0.0001).High volume boluses were associated with more major impedance events (≥ 10 mL boluses = 63%,3 mL boluses = 17%,and 3 mL boluses = 0%,P = 0.02).CONCLUSION: Bolus volume had an impact on the type and length of propagation of SI impedance events and a threshold of 2 mL is required to produce an event.