ABC transporters,neural stem cells and neurogenesis - a different perspective
ABC transporters,neural stem cells and neurogenesis - a different perspective作者机构：Department of Molecular and Cell Biology School of Biological Sciences Nanyang Technological University 60 Nanyang Drive Singapore 637551
出 版 物：《Cell Research》 (细胞研究(英文版))
年 卷 期：2006年第16卷第11期
页 面：857-871页
核心收录：
学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 07[理学] 071006[理学-神经生物学]
基 金：^ANANYANG TECHNOLOGICAL UNIVERSITY^BSBS/SUG/22/04^D1
主 题：neural stem cells ABC transporters ABCB1 ABCG2 differentiation stem cell marker
摘 要：Stem cells intrigue.They have the ability to divide exponentially,recreate the stem cell compartment,as well as cre-ate differentiated cells to generate tissues.Therefore,they should be natural candidates to provide a renewable sourceof cells for transplantation applied in regenerative medicine.Stem cells have the capacity to generate specific tissues oreven whole organs like the blood,heart,or bones.A subgroup of stem cells,the neural stem cells(NSCs),is characterizedas a self-renewing population that generates neurons and glia of the developing brain.They can be isolated,geneticallymanipulated and differentiated in vitro and reintroduced into a developing,adult or a pathologically altered central nervoussystem.NSCs have been considered for use in cell replacement therapies in various neurodegenerative diseases such asParkinson’s disease and Alzheimer’s disease.Characterization of genes with tightly controlled expression patterns duringdifferentiation represents an approach to understanding the regulation of stem cell commitment.The regulation of stemcell biology by the ATP-binding cassette(ABC)transporters has emerged as an important new field of investigation.Asa major focus of stem cell research is in the manipulation of cells to enable differentiation into a targeted cell population;in this review,we discuss recent literatures on ABC transporters and stem cells,and propose an integrated view on therole of the ABC transporters,especially ABCA2,ABCA3,ABCB1 and ABCG2,in NSCs’ proliferation,differentiationand regulation,along with comparisons to that in hematopoietic and other stem cells.
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