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ABC transporters,neural stem cells and neurogenesis - a different perspective

Cell Research 2006年第11期16卷 857-871页

作者： omedulislam KlausHeese Department of Molecular and Cell Biology School of Biological SciencesNanyang Technological University60 Nanyang DriveSingapore 637551Singapore

Stem cells *** have the ability to divide exponentially,recreate the stem cell compartment,as well as cre-ate differentiated cells to generate ***,they should be natural candidates to provide a renewable sourceof cells for transplantation applied in regenerative *** cells have the capacity to generate specific tissues oreven whole organs like the blood,heart,or bones.A subgroup of stem cells,the neural stem cells(NSCs),is characterizedas a self-renewing population that generates neurons and glia of the developing *** can be isolated,geneticallymanipulated and differentiated in vitro and reintroduced into a developing,adult or a pathologically altered central *** have been considered for use in cell replacement therapies in various neurodegenerative diseases such asParkinson’s disease and Alzheimer’s *** of genes with tightly controlled expression patterns duringdifferentiation represents an approach to understanding the regulation of stem cell *** regulation of stemcell biology by the ATP-binding cassette(ABC)transporters has emerged as an important new field of *** major focus of stem cell research is in the manipulation of cells to enable differentiation into a targeted cell population;in this review,we discuss recent literatures on ABC transporters and stem cells,and propose an integrated view on therole of the ABC transporters,especially ABCA2,ABCA3,ABCB1 and ABCG2,in NSCs’ proliferation,differentiationand regulation,along with comparisons to that in hematopoietic and other stem cells.

关键词： neural stem cells ABC transporters ABCB1 ABCG2 differentiation stem cell marker

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