Intestinal sugar transport

作     者：Laurie A Drozdowski Alan BR Thomson 

作者机构：Division of Gastroenterology Department of MedicineUniversity of Alberta5150 Dentistry Pharmacy BuildingEdmontonABT6G 2N8Canada 130 University Campus Division of GastroenterologyDepartment of MedicineUniversity of AlbertaZeidler Ledcor CenterEdmontonABT6G 2X8Canada 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2006年第12卷第11期

页      面：1657-1670页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Glucose Fructose SGLT1 GLUT2 GLUT5 Transport Intestine Enterocytes Sugar 

摘      要：Carbohydrates are an important component of the diet. The carbohydrates that we ingest range from simple monosaccharides （glucose, fructose and galactose） to disaccharides （lactose, sucrose） to complex polysaccharides. Most carbohydrates are digested by salivary and pancreatic amylases, and are further broken down into monosaccharides by enzymes in the brush border membrane （BBM） of enterocytes. For example, lactase-phloridzin hydrolase and sucraseisomaltase are two disaccharidases involved in the hydrolysis of nutritionally important disaccharides. Once monosaccharides are presented to the BBM, mature enterocytes expressing nutrient transporters transport the sugars into the enterocytes. This paper reviews the early studies that contributed to the development of a working model of intestinal sugar transport, and details the recent advances made in understanding the process by which sugars are absorbed in the intestine.