Design,characterisation,and clinical evaluation of a novel porous Ti-6Al-4V hemipelvic prosthesis based on Voronoi diagram
作者机构：Orthopaedic Research Institute and Department of OrthopaedicsWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Model Worker and Craftsman Talent Innovation Workshop of Sichuan ProvinceChengduSichuan ProvinceChina Tianqi Additive Manufacturing Co.LtdChengduSichuan ProvinceChina Department of Orthopaedic SurgerySarcoma Biology LaboratorySylvester Comprehensive Cancer Centreand The University of Miami Miller School of MedicineMiamiFLUSA
出 版 物：《Biomaterials Translational》 (生物材料转化电子杂志（英文）)
年 卷 期：2024年第5卷第3期
页 面：314-324页
学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）]
基 金：supported by Qingdao Research Institutes of Sichuan University Research of Biomedical Materials and 3D Printing Related Products(No.20GZ30301)
主 题：3D printing biomimetic prosthesis bone tumour pelvic defect reconstruction porous structure
摘 要：Three-dimensional printed Ti-6Al-4V hemipelvic prosthesis has become a current popular method for pelvic defect *** paper presents a novel biomimetic hemipelvic prosthesis design that utilises patient-specific anatomical data in conjunction with the Voronoi diagram *** traditional design methods that rely on fixed,homogeneous unit cell,the Voronoi diagram enables to create imitation of trabecular structure(ITS).The proposed approach was conducted for six *** entire contour of the customised prosthesis matched well with the residual *** porosity and pore size of the ITS were *** distribution of the pore size ranged from 500 to 1400μ*** calculations indicated the average porosity was 63.13±0.30%.Cubic ITS samples were fabricated for micrograph and mechanical *** electron microscopy images of the ITS samples exhibited rough surface morphology without obvious *** Young’s modulus and compressive strength were 1.68±0.05 GPa and 174±8 MPa,***-operative X-rays confirmed proper matching of the customised prostheses with the bone ***-Shimadzu metal artifact reduction technology images indicated close contact between the implant and host bone,alongside favourable bone density and absence of resorption or osteolysis around the *** the last follow-up,the average Musculoskeletal Tumour Society score was 23.2(range,21-26).By leveraging additive manufacturing and Voronoi diagram algorithm,customised implants tailored to individual patient anatomy can be fabricated,offering wide distribution of the pore size,reasonable mechanical properties,favourable osseointegration,and satisfactory function.
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