Multi-functional epoxides cross-linked collagen sponges for tissue engineering scaffolds

作     者：Yuanzhi Zhang Changkai Yang Min Gu Xiaoxia Zhang Xueqing Zhang Guoying Li 

作者机构：National Engineering Laboratory for Clean Technology of Leather ManufactureSichuan University Key Laboratory of Leather Chemistry and Engineering (Sichuan University)Ministry of Education Max Planck Institute for Polymer Research 

出 版 物：《Collagen and Leather》 (胶原与皮革(英文))

年 卷 期：2024年第1期

页      面：127-140页

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：financially supported by the National Natural Science Foundation of China (No.22078206) 

摘      要：With the efficient cross-linking abilities and the flexible regulation abilities to the performances of cross-linked products,the multi-functional aliphatic epoxides were once widely used to cross-link the collagen-based materials in the last *** present work,the multi-functional epoxides were used to construct and cross-link collagen sponges for tissue engineering scaffolds,which was hoped to board the theoretical system of epoxides and explore their potentials for modern *** bi-to tetra-functional epoxides were used to cross-link collagen solutions and establish the gel-like precursors,then using freeze-drying to form the final *** SEM observed that the sponges had shown regular porous structures with a wide range of pore sizes from 160 to 440 μ*** sponges had presented the resistance to enzymatic degradation,shape-remaining ability,and reversible compressibility in aqueous environments,which all could be regulated through the functionalities of *** regulation abilities of multi-functional epoxides on the performances of sponges had been mainly achieved through the crosslinking degrees that the higher functionality of epoxides would bring higher cross-linking *** higher crosslinking degrees could enhance the elastic behaviors of gel-like precursors,and improve the compressive strengths and thermal stabilities of ***,the multi-functional epoxides had barely affected the safety of collagen sponges at the cellular level according to the results of CCK8 assay and the SEM and CLSM images of L929fibroblasts cultured on the cross-sections of sponges.