Clinical meaning of BRAF mutation in Korean patients with advanced colorectal cancer

作     者：Bun Kim Soo Jung Park Jae Hee Cheon Tae Il Kim Won Ho Kim Sung Pil Hong 

作者机构：Department of Internal MedicineInstitute of GastroenterologyYonsei University College of MedicineSeoul 120-752South Korea 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第15期

页      面：4370-4376页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：BRAF Colorectal cancer Molecular features Chemotherapy response Prognosis 

摘      要：AIM: To evaluate the clinicopathological features of colorectal cancer (CRC) with a v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) mutation and its molecular interaction with microsatellite instability (MSI) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) in patients with advanced CRCs.