Tetrahedral framework nucleic acids/hyaluronic acid-methacrylic anhydride hybrid hydrogel with antimicrobial and anti-inflammatory properties for infected wound healing
作者机构：State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology Sichuan University Sichuan Provincial Engineering Research Center of Oral Biomaterials Department of Stomatology The First Medical CentreChinese PLA General Hospital
出 版 物：《International Journal of Oral Science》 (国际口腔科学杂志(英文版))
年 卷 期：2024年第03期
页 面：436-447页
核心收录：
学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）]
基 金：supported by National Key R&D Program of China (2019YFA0110600) National Natural Science Foundation of China (82370929, 81970916) Sichuan Science and Technology Program (2022NSFSC0002) Sichuan Province Youth Science and Technology Innovation Team (2022JDTD0021) Research and Develop Program West China Hospital of Stomatology Sichuan University (RD03202302)
摘 要：Bacterial resistance and excessive inflammation are common issues that hinder wound healing. Antimicrobial peptides(AMPs) offer a promising and versatile antibacterial option compared to traditional antibiotics, with additional anti-inflammatory ***, the applications of AMPs are limited by their antimicrobial effects and stability against bacterial degradation. TFNAs are regarded as a promising drug delivery platform that could enhance the antibacterial properties and stability of ***, in this study, a composite hydrogel(HAMA/t-GL13K) was prepared via the photocross-linking method, in which tFNAs carry GL13K. The hydrogel was injectable, biocompatible, and could be instantly photocured. It exhibited broad-spectrum antibacterial and anti-inflammatory properties by inhibiting the expression of inflammatory factors and scavenging ROS. Thereby,the hydrogel inhibited bacterial infection, shortened the wound healing time of skin defects in infected skin full-thickness defect wound models and reduced scarring. The constructed HAMA/tFNA-AMPs hydrogels exhibit the potential for clinical use in treating microbial infections and promoting wound healing.
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