Dietary supplementation with pterostilbene activates the PI3K‑AKT‑mTOR signalling pathway to alleviate progressive oxidative stress and promote placental nutrient transport

作     者：Mingming Cao Liyun Bai Haoyun Wei Yantong Guo Guodong Sun Haoyang Sun Baoming Shi 

作者机构：College of Animal Science and TechnologyNortheast Agricultural UniversityHarbin 150030PR China 

出 版 物：《Journal of Animal Science and Biotechnology》 (畜牧与生物技术杂志(英文版))

年 卷 期：2025年第16卷第1期

页      面：388-407页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Natural Science Foundation of Heilongjiang Province(YQ2022C014) National Natural Science Foundation of China(32302768) 

主　　题：Nutrient transporters Placenta Progressive oxidative stress Pterostilbene Sows 

摘      要：Background Progressive oxidative stress easily occurs as a result of a gradual increase in the intensity of maternal metabolism due to rapid foetal development and increased intensity of ***,studies on the effects of processive oxidative stress on nutrient transport in the placenta have received little *** present study was conducted on sows at 85 days of gestation to study the effects of pterostilbene(PTE)on maternal oxidative stress status and placental nutrient *** PTE increased the antioxidant capacity and immunoglobulin content in mothers’blood and milk,reduced the level of inflammatory factors,and improved the nutrient content of *** also reduced sow backfat loss and the number of weak sons,and increased piglet weaning weight and total weaning litter *** subsequently found that PTE enhanced placental glucose and fatty acid transport and further affected glycolipid metabolism by increasing the expression of LAL,PYGM,and Gbe-1,which activated the PI3K phosphorylation ***,PTE addition altered the relative abundance of the Firmicutes,Proteobacteria,Parabacillus,and Bacteroidetes-like RF16 groups in sow *** increased the levels of acetate,propionate,butyrate and isovalerate in the *** These findings reveal that the addition of PTE during pregnancy and lactation mitigates the effects of processive oxidative stress on offspring development by altering maternal microbial and placental nutrient trans-port capacity.