The imaging and dissecting of pBR322 plasmid DNA by AFM

作     者：Tian, F Li, JW Wang, C Bai, CL 

作者机构：Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China 

出 版 物：《Chinese Science Bulletin》 (中国科学通报)

年 卷 期：1997年第42卷第13期

页      面：1093-1096页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：This project was supported by the Grant of Chinese Academy of Sciences (KJ951-A1-502) the National Natural Science Foundation of China (19634010) 

主　　题：atomic force microscope plasmid DNA probe force. 

摘      要：THE intra- and intermolecular forces of DNA are essential to understanding its structure andfunctional behavior. However, direct measurement of interaction forces requires that the stateof a system be monitored simultaneously while an independent force is applied. Until now, on-ly X-ray crystallography, light scattering, and nuclear magnetic resonance spectroscopy havebeen used to measure these molecular forces using indirect physical and thermodynamic meth-