透明质酸调节肠道微生物和代谢物缓解炎症:一项分子量依赖性研究（英文）

作     者：张川 王伯韬 于雷雷 赵若寒 张青松 张程程 崔树茂 赵建新 Arjan Narbad 陈卫 田丰伟 翟齐啸 

作者机构：State Key Laboratory of Food Science and Technology Jiangnan University School of Food Science and Technology Jiangnan University Bloomage Biotechnology Co. Ltd. International Joint Research Laboratory for Probiotics Jiangnan University Gut Health and Microbiome Institute Strategic Programme Quadram Institute Bioscience 

出 版 物：《Science Bulletin》 (科学通报(英文版))

年 卷 期：2024年第17期

页      面：2683-2687页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0836[工学-生物工程] 

基　　金：supported by the National Natural Science Foundation of China General Program (32372296) the Natural Science Foundation of Jiangsu Province (BK20220155) the National Key Research and Development Project of China (2022YFF1100203) the Key Scientific and Technological Research Projects in the Key Areas of the Xinjiang Production and Construction Corps (2018AB010) Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province 

摘      要：Hyaluronic acid(HA), a linear glycosaminoglycan polymer, is an inherent carbon source for gut microbiota and is capable of mitigating host inflammation by modulating gut microbiota. The length of hyaluronan can range from an oligomer to an extremely long-form up to millions of Daltons, and its biological functions depend on its molecular mass [1,2]. Presently, the precise mechanisms through which HA of varying molecular weights alleviates inflammation by modulating the gut microbiota remain unclear [3].