Metabolic inflexibility of mitochondria: beneficial for the fitness of regenerating liver cells

作     者：Josef Ecker Sarah Brunner Klaus-Peter Janssen 

作者机构：Institute of Clinical Chemistry and Laboratory MedicineFunctional Lipidomics and Metabolism ResearchUniversity Hospital RegensburgRegensburgGermany Department of SurgerySchool of Medicine and HealthTechnical University of Munich81675MunichGermany 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2024年第9卷第10期

页      面：4154-4156页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Springer Nature and German Universities Deutsche Forschungsgemeinschaft, DFG, (395357507 – SFB 1371) Deutsche Forschungsgemeinschaft, DFG 

主　　题：metabolism liver Metabolic 

摘      要：In a recent manuscript in Science,Wang and coworkers discovered that metabolic inflexibility is required for proper mitochondrial function during liver regeneration.1 This study deepens our understanding of liver metabolism,stem cell biology and adult tissue renewal,suggesting that metabolic flexibility,generally assumed to be a selective advantage,may actually be detrimental for mitochondrial function in the regenerating liver.