一种可抑制脓毒症的促愈合短链抗菌肽（英文）

作     者：任泽凯 丁鑫 王玉梅 吴晗 刘鑫 曹阳 丛海林 申有青 于冰 

作者机构：College of Chemistry and Chemical Engineering College of Materials Science and Engineering Institute of Biomedical Materials and Engineering Qingdao University State Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao University School of Materials Science and Engineering Shandong University of Technology Key Laboratory of Biomass Chemical Engineering of Ministry of Education Center for Bionanoengineering and Department of Chemical and Biological Engineering Zhejiang University 

出 版 物：《Science China Materials》 (中国科学:材料科学(英文版))

年 卷 期：2024年

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：supported by the National Natural Science Foundation of China (22074072 and 22274083) Shandong Provincial Natural Science Foundation (ZR2022LZY022 and ZR2023LZY005) the Science and Technology Planning Project of South District of Qingdao City (2022-4-005-YY) the Exploration project of the State Key Laboratory of BioFibers and EcoTextiles of Qingdao University (TSKT202101) the National Key R&D Program of China (2024YFE0104100) the Medical Plus Key Project of Qingdao University (YX2024201) 

摘      要：慢性伤口遭遇多药耐药菌感染是致命的,严重者会引发脓毒症.抗菌肽的广谱抗菌特性和良好的抗耐药性被广泛用于伤口护理领域.我们以SiO2微球为固定相,提取细菌的细胞膜制备细菌细胞膜色谱（BCMC）.固相法合成抗菌肽文库并经BCMC筛选出抗菌肽LKAHR （简称LS5）. LS5具有生物安全、广谱抗菌以及抗耐药性等特点,制备明胶基抗菌水凝胶（LS5-gel）以更好应用于伤口.在伤口愈合模型中发现LS5-gel具有良好的体内杀菌性能以及促进伤口愈合能力.在脓毒症模型中发现LS5对脓毒症感染具有明显的抑制作用.本工作对下一代抗菌药物的选取及慢性伤口愈合治疗具有重要指导意义.