Effect of Chaiqinchengqi decoction on serum amyloid A in severe acute pancreatitis patients

作     者：Wei Wu Jia Guo Xiao-Nan Yang Zi-Qi Lin zhen-Zhen Huang Qing Xia Ping Xue 

作者机构：Pancreatic Diseases Research GroupDepartment of Integrated Traditional and Western MedicineWest China HospitalSichuan University Department of SurgeryFirst Hospital of Chengdu 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2012年第5卷第11期

页      面：901-905页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by National Natural Science Foundation of China(No. 81072910) Science and Technology Supports Program of Sichuan(No.2009SZ0201, 2010SZ0068,2011SZ029) 

主　　题：Severe acute pancreatitis Chaiqinchengqi decoction Serum amyloid A 

摘      要：Objective:To investigate the effect of Chaiqinchengqi decoction(CQCQD) on serum amyloid A (SAA) in severe acute pancreatitis(SAP) ***:Thirty-five participants enrolled and were randomly assigned into either a treatment condition(n=17,treated with CQCQD) or a control condition(n=18,treated with placebo) 24 hours following the onset of the disease. No statistical difference was observed in either group at *** admission,the Acute Physiology and Chronic Health Evaluation scoreⅡ(APACHEⅡ),SAA,serum C-reactive protein (CRP) and interleukin-6(IL-6) were measured,as well as on the first,3rd and 7lh day and were compared between the two *** complications,infection,operation rate,mortality and hospital stay were also ***:The duration of acute respiratory distress syndrome, acute hepatitis,acute renal failure,gastrointestinal failure and blood coagulation dysfunction were shorter in the treatment group than in those in the control group(P0.05).The secondary infection rates and the hospital fees in the treatment group were lower than those in the control group(P0.05) as well as length of hospital stay(P0.01).After 3 days of hospitalization,the APACHEⅡ,score SAA levels,serum CRP and IL-6 in the treatment group was lower than those in the control group(P0.05).SAA was positively correlated with serum CRP(R = 0.346,P = 0.042),Ranson score(R = 0.442,P = 0.008) and serum IL-6(R=0.359,P =0.034).The area under the receiver operating characteristic curve of admission SAA predict pancreatic necrosis(PN) was 0.815(95%CI:0.625-0.954;P =0.006).The best cut-off value of admission SAA was 7.85 mg/L with the sensitivity 84.6%and specificity 68.2%.Conclusions:The CQCQD can reduce the duration of organ damage through lowering the SAA in SAP patients and the SAA can early predict the PN and severity of SAP patients.