Potential protective effects of Clostridium butyricum on experimental gastric ulcers in mice
Potential protective effects of Clostridium butyricum on experimental gastric ulcers in mice作者机构：State Key Laboratory of Organ Failure Research Nanfang Hospital Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China Key Laboratory of Proteomics of Guangdong Province Department of Pathophysiology Southern Medical University Department of Pathophysiology Wenzhou Medical University School of Environmental Science and Public Health Wenzhou Medical University
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2015年第21卷第27期
页 面：8340-8351页
核心收录：
基 金：Supported by grants from The National Key Basic Research(973)Program of China,No.2010CB529704(to Jiang Y) the National Natural Science Foundation of China,No.81030055,and No.81372030(to Jiang Y) the Guangdong Provincial Natural Science Foundation(S2013010014422)(to Liu A) the Program of Wenzhou Sci-tech Museum,No.Y20130215(to Wang FY)
主 题：Inflammation Probiotics Oxidative stress Clostridium butyricum Gastric ulcer
摘 要：AIM: To investigate the effects of Clostridium butyricum(C. butyricum) on experimental gastric ulcers(GUs) induced by alcohol, restraint cold stress, or pyloric ligation in mice, respectively.METHODS: One hundred and twenty mice were randomly allocated into three types of gastric ulcer models(n = 40 each), induced by alcohol, restraint cold stress, or pyloric ligation. In each GU model, 40 mice were allocated into four groups(n = 10 each): the sham control group; model group(GU induction without pretreatment); C. butyricum group(GU induction with C. butyricum pretreatment); and Omeprazole group(GU induction with Omeprazole pretreatment). Theeffects of C. butyricum were evaluated by examining the histological changes in the gastric mucosal erosion area, the activities of superoxide dismutase(SOD) and catalase(CAT), the level of malondialdehyde(MDA), and the contents of interleukin(IL)-1b, tumor necrosis factor(TNF)-α, leukotriene B4(LTB4) and 6-keto-PGF-1α(degradation product of PGI2) in the gastric tissue.RESULTS: Our data showed that C. butyricum significantly reduced the gastric mucosal injury area and ameliorated the pathological conditions of the gastric mucosa. C. butyricum not only minimized the decreases in activity of SOD and CAT, but also reduced the level of MDA in all three GU models used in this study. The accumulation of IL1-b, TNF-α and LBT4 decreased, while 6-keto-PGF-1α increased with pretreatment by C. butyricum in all three GU models.CONCLUSION: Our data demonstrated the protective effects of pretreatment with C. butyricum on antioxidation and anti-inflammation in different types of GU models in mice. Further studies are needed to explore its potential clinical benefits.
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