Raman spectroscopy of Chinese human skin in vivo

作     者：李永增 陈荣 曾海山 黄志伟 冯尚源 谢树森 

作者机构：Key Laboratory of Optoelectronic Science and Technology for Medicine (Fujian Normal University)Ministry of EducationFuzhou 350007 Cancer Imaging DepartmentBC Cancer AgencyVancouverCanada 

出 版 物：《Chinese Optics Letters》 (中国光学快报（英文版）)

年 卷 期：2007年第5卷第2期

页      面：105-107页

核心收录：

学科分类：0808[工学-电气工程] 070207[理学-光学] 0809[工学-电子科学与技术（可授工学、理学学位）] 07[理学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0803[工学-光学工程] 0702[理学-物理学] 

基　　金：This work was supported by the Key Project of Ministry of Education (No. 205081) the Project of Fujian Province (No. 20051009, JA04168) the Project of Fujian Development and Reform Commission (No.2005-847) 

主　　题：Aberrations Charge coupled devices Detectors Optical fibers Polynomials Raman scattering Semiconductor lasers Signal to noise ratio Skin 

摘      要：A novel and compact near-infrared （NIR） Raman system is developed using 785-nm diode laser, volumephase technology （VPT） holographic system, and NIR intensified charge-coupled device （CCD）. Signal-tonoise ratio （SNR） and resolution are improved compared with ordinary acquisition method by a specially designed optical fiber detector and the spectrograph image aberration correction with a parabolic-line fiber array. In 1-5 s, Raman spectra of different parts of Chinese human skin are acquired. Autofluorescence is subtracted from the raw spectrum by polynomial fitting and skin Raman spectrum is then smoothed for further analysis.