Biophysical and biorheological studies on the precursor cells at different stages
Biophysical and biorheological studies on the precursor cells at different stages作者机构：Department of Medical Physics Basic Medical School of Peking University Beijing 100083 China
出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)
年 卷 期：2002年第45卷第4期
页 面：421-428页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：This work was supported by the National Natural Science Foundation of China (Grant No. 39830110)
主 题：precursor cell, electrophoretic mobility, osmotic fragility, membrane fluidity, membrane viscoelastic properties.
摘 要：Splenic erythroblasts were obtained from mice during the acute disease caused by anemia-inducing virus (FVA). They were cultured in a medium containing EPO, BSA and so on. We studied their biomechanical and hemorheological behavior after 12 h, 24 h and 48 h. The results showed obvious changes in their electrophoretic mobility, osmotic fragility, membrane fluidity and membrane viscoelastic properties with the development of erythroblast. The changes were associated with the interactions of the protein and lipid and the elements of the membrane.
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