Expression of class Ⅰ MHC molecule,HSP70 and TAP in human hepatocellular carcinoma

作     者：Xiao-Ling Deng Wei Chen Mei-Ying Cai Da-Peng Wei, Immunology Department, West China Medical Center of Sichuan University, Chengdu 610044, Sichuan Province, China 

作者机构：Immunology Department West China Medical Center of Sichuan University Chengdu 610044 Sichuan Province China. 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2003年第9卷第8期

页      面：1853-1855页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the National Natural Science Foundation of China No.30070855 

主　　题：肝细胞癌 热休克蛋白70 主要组织相容性抗原复合物 TAP 

摘      要：AIM:To demonstrate whether class I MHC molecule,transporter associated with antigen processing (TAP), and heat-shock proteion70 (HSP70) expressed in liver cancer cells before the design and construction of CTL vaccine against hepatocellular carcinoma (HCC).METHODS: We studied 30 HCC specimens by labeled streptavidin biotin (LSAB) method of ***: The results showed that the majority of HCC cells investigated naturally expressed class I MHC and TAP,which were different from other tumor cells. Furthermore,we found that HSP70 expressed not only in cellularcytoplasm, but also on the cell surface in ***: Our findings indicate that our understanding about immune escape mechanisms employed by HCC cells may be further improved, It is important to design and construct CTL vaccine against HCC.