Morphology of spinal cord extracellular matrix-derived acellular scaffolds fabricated in rats

作     者：Wenhua Yin Kaiwu Lu Dadi Jin 

作者机构：Department of Orthopedic Surgery Yuebei People's Hospital Affiliated to Shantou Medical College of Shantou University Shaoguan 512026 Guangdong Province China Department of Spine Surgery Nanfang Hospital Affiliated to Southern Medical University Guangzhou 510515 Guangdong Province China Institute of Orthopedic Research Southern Medical University Guangzhou 510630 Guangdong Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2011年第6卷第10期

页      面：767-771页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：Science Foundation of Shaoguan in Guangdong Province, No. 2010-07 the Natural Science Foundation of Guangdong Province, China, No. 10451202602005995 

主　　题：spinal cord extracellular matrix decellularization scaffolds neural regeneration 

摘      要：Acellular peripheral allograft scaffolds can be fabricated using chemical extraction techniques,but methods for producing acellular scaffold derived from spinal cord tissue are not currently *** present study demonstrated that chemical extraction using Triton X-100 and sodium deoxycholate could be used to completely remove the cells,axons and neural sheaths in spinal cord extracellular matrix-derived *** matrix fibers were longitudinally arranged in a wave-like formation,and were connected by fiber ***-shaped fiber cages appeared and developed into bone trabecula-like *** natural structure of matrix fibers in the scaffolds was maintained;this helps to guide the differentiation and migration of implanted stem *** spinal cord extracellular matrix-derived scaffolds can provide an ideal substance for fabricating tissue-engineered spinal cord.