Determination of related substances in disulfide-rich peptide ziconotide by establishing tandem mass spectrometry methods

作     者：Yuya Cheng Peize Wu Peng Xiao Ming Li Yuya Cheng;Peize Wu;Peng Xiao;Ming Li

作者机构：Division of Chemical Metrology&Analytical ScienceNational Institute of MetrologyBeijing100029China 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2024年第14卷第10期

页      面：1535-1537页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：The authors thank the funding from the National Key R&D Program of China(Grant No.:2021YFF0600704 and 2021YFF0600701) 

主　　题：disulfide establishing insertion 

摘      要：Currently,several disulfide-rich peptides have been officially approved as therapeutic medicines,such as w-conotoxin ziconotide[1],guanosine analogue linaclotide,and *** are predisposed to generate related substances(also termed as structurally related impurities)including amino acid deletion/insertion,diastereoisomerization,deamination/amination,oxidation,and succinimidation etc.