Construction of degradable liposome-templated microporous metal-organic frameworks with commodious space for enzymes

作     者：Cheng Cheng Nasir Ali Ji Liu Juan Qiao Ming Wang Li Qi Cheng Cheng;Nasir Ali;Ji Liu;Juan Qiao;Ming Wang;Li Qi

作者机构：Beijing National Laboratory for Molecular SciencesKey Laboratory of Analytical Chemistry for Living BiosystemsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China College of Chemistry&Environmental ScienceHebei UniversityBaoding 071002China School of Chemical SciencesUniversity of Chinese Academy of SciencesBeijing 100049China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第11期

页      面：294-298页

核心收录：

学科分类：081705[工学-工业催化] 08[工学] 0817[工学-化学工程与技术] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 082203[工学-发酵工程] 0822[工学-轻工技术与工程] 

基　　金：the financial support from the National Natural Science Foundation of China(No.22274159) 

主　　题：Metal organic frameworks Degradable liposomes Enzyme conformational freedom Nanoreactor Biocatalysis 

摘      要：The construction of enzyme reactors based on metal-organic frameworks(MOFs)as the immobilized matrix is a proven strategy that has achieved the widespread application of enzymes across *** many MOFs and a variety of strategies have been developed,a formidable challenge remains in maintaining the high enzyme activity with excellent recyclability and tolerance for harsh ***,using degradable redox stimuli-responsive liposomes as the templates with microporous MOFs(M-MOFs)as the hosts for enzyme encapsulation,a series of enzyme reactors(enzyme@M-MOFs)was designed and *** on the premise of enhancing enzyme protection in the harsh environment,this strategy provided a high degree-of-freedom space via removal of liposomes that improved the conformational freedom of the enzymes,promoted the mass transfer of substrates and products,and greatly boosted the catalytic ***,the strategy had good universality and was applied to various liposomes,M-MOFs and ***,the co-encapsulation of different enzymes with synergistic functions was performed using the M-MOFs *** study solved the problems of the conformation limitation of enzymes and mass transfer resistance of substrates and products using the proposed enzyme@M-MOFs,providing a new approach for the construction of biological cascade reaction devices based on MOFs materials.