Amide Proton Transfer Magnetic Resonance Imaging of Alzheimer＇s Disease at 3.0 Tesla： A Preliminary Study

作     者：Rui Wang Sa-Ying Li Min Chen Jin-Yuan Zhou Dan-Tao Peng Chen Zhang Yong-Ming Dai Wang Rui;Li Sa-Ying;Chen Min;Zhou Jin-Yuan;Peng Dan-Tao;Zhang Chen;Dai Yong-Ming

作者机构：Department of Radiology Beijing Hospital Beijing 100730 China Department of Radiology Division of MR Research Johns Hopkins University Baltimore Maryland 21287 USA Department of Neurology China-Japan Friendship Hospital Beijing 100029 China Imaging System Philips Healthcare MR Shanghai 200233 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2015年第128卷第5期

页      面：615-619页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 07[理学] 0809[工学-电子科学与技术（可授工学、理学学位）] 070205[理学-凝聚态物理] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0702[理学-物理学] 10[医学] 

基　　金：the National Science and Technology Pillar Program during the 12~(th) Five-year Plan Period of China 美国国立卫生研究院(NIH)项目 

主　　题：Alzheimer's Disease Amide Proton Transfer Imaging Molecular Imaging 

摘      要：Background：Amide proton transfer （APT） imaging has recently emerged as an important contrast mechanism for magnetic resonance imaging （MRI） in the field of molecular and cellular *** aim of this study was to evaluate the feasibility of APT imaging to detect cerebral abnormality in patients with Alzheimer＆#39;s disease （AD） at 3.0 ***：Twenty AD patients （9 men and 11 women; age range,67-83 years） and 20 age-matched normal controls （11 men and 9 women; age range,63-82 years） underwent APT and traditional MRI examination on a 3.0 Tesla MRI *** magnetic resonance ratio asymmetry （MTRasym） values at 3.5 ppm of bilateral hippocampi （Hc）,temporal white matter regions,occipital white matter regions,and cerebral peduncles were measured on oblique axial APT *** （3.5 ppm） values of the cerebral structures between AD patients and control subjects were compared with independent samples *** for age,partial correlation analysis was used to investigate the associations between mini-mental state examination （MMSE） and the various MRI measures among AD ***：Compared with normal controls,MTRasym （3.5 ppm） values of bilateral Hc were significantly increased in AD patients （right 1.24% ± 0.21% vs.0.83% ± 0.19%,left 1.18% ± 0.18% vs.0.80%± 0.17%,t =3.039,3.328,P =0.004,0.002,respectively）.MTRasym （3.5 ppm） values of bilateral Hc were significantly negatively correlated with MMSE （right r =-0.559,P =0.013; left r=-0.461,P =0.047）.Conclusions：Increased MTRasym （3.5 ppm） values of bilateral Hc in AD patients and its strong correlations with MMSE suggest that APT imaging could potentially provide imaging biomarkers for the noninvasive molecular diagnosis of AD.