ENDOCRINE CHANGES OF PARALICHTHYS OLIVACEUS AFTER ORAL ADMINISTRATION WITH EXOGENOUS GROWTH HORMONE

作     者：刘宗柱 徐德武 王勇 徐永立 张培军 

作者机构：Institute of Oceanology Chinese Academy of Sciences Qingdao China Dep. Anim. Sci. Laiyang Agriculture College Laiyang China 

出 版 物：《Chinese Journal of Oceanology and Limnology》 (中国海洋湖沼学报（英文版）)

年 卷 期：2000年第18卷第4期

页      面：315-319页

核心收录：

学科分类：07[理学] 

基　　金：NationalKeyProblemforthe"Ninth Five Year Plan" (96 C0 1 0 5 0 4) 

主　　题：growth hormone receptor IGF I T 3 T 4 

摘      要：Recombinant salmon growth hormone contained in yeast was given for 5 months to flounder in its diet. Both free and total specific binding sites for the growth hormone were examined in liver membranes of control and treated fish. The association constants of both free and total specific binding sites were of the same order (1 nM 1 ), and no significant difference was found between any two groups in the capacity of their free binding sites. The capacity of total binding sites in the liver of treated fish increased significantly compared with that of control. Insulin like growth factor I (IGF I) levels in the plasma of treated fish increased by 22.61% (P0.05), compared with that of control. While the T 4 levels in plasma did not increase significantly (from 1.35±0.91 ng/ml to 2.29±1.13 ng/ml), T 3 levels were elevated significantly (from 1.78±1.14 ng/ml to 4.87±1.22 ng/ml, P0.01), as compared with that of control.