Hepatocyte growth factor, a biomarker of macroangiopathy in diabetes mellitus

作     者：Hiroyuki Konya Masayuki Miuchi Kahori Satani Satoshi Matsutani Taku Tsunoda Yuzo Yano Tomoyuki Katsuno Tomoya Hamaguchi Jun-Ichiro Miyagawa Mitsuyoshi Namba 

作者机构：Department of Internal Medicine Ashiya Municipal Hospital Ashiya Hyogo 659-8502 Japan Division of Diabetes Endocrinology and Metabolism Department of Internal Medicine Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Departmentof Internal Medicine Ashiya Municipal Hospital Ashiya Hyogo 659-8502 Japan Division of Innovative Diabetes TreatmentDepartment of Internal Medicine Hyogo College of MedicineNishinomiya Hyogo 663-8501 Japan Division of Diabetes Department of Internal Medicine Itami City Hospital Itami Hyogo 664-8540 Japan 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2014年第5卷第5期

页      面：678-688页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Hepatocyte growth factor Diabetes mellitus Carotid atherosclerosis Macroangiopathy Biomarker 

摘      要：Atherosclerotic involvements are an essential causal element of prospect in diabetes mellitus(DM), with carotid atherosclerosis(CA) being a common risk-factor for prospective crisis of coronary artery diseases(CAD) and/or cerebral infarction(CI) in DM subjects. From another point of view, several reports have supplied augmenting proof that hepatocyte growth factor(HGF) has a physiopathological part in DM involvements. HGF has been a mesenchymal-derived polyphenic factor which modulates development, motion, and morphosis of diverse cells, and has been regarded as a humor intermediator of epithelial-mesenchymal interplays. The serum concentrations of HGF have been elevated in subjects with CAD and CI, especially during the acute phase of both disturbances. In our study with 89 type 2 DM patients, the association between serum concentrationsof HGF and risk-factors for macrovascular complicationsinclusive of CA were examined. The average of serumHGF levels in the subjects was more elevated than thereference interval. The serum HGF concentrations associated positively with both intimal-media thickness(IMT)(r = 0.24, P = 0.0248) and plaque score(r = 0.27, P =0.0126), indicating a relationship between the elevatedHGF concentrations and advancement of CA involvements. Multivariate statistical analysis accentuated thatserum concentrations of HGF would be associated inde-pendently with IMT(standardized = 0.28, P = 0.0499).The review indicates what is presently known regardingserum HGF might be a new and meaningful biomarkerof macroangiopathy in DM subjects.