G6PT-H6PDH-11βHSD1 triad in the liver and its implication in the pathomechanism of the metabolic syndrome

作     者：Ibolya Czegle Miklós Csala József Mandl Angelo Benedetti István Karádi Gábor Bánhegyi 

作者机构：3rd Department of Internal Medicine Semmelweis University 1125 Budapest Hungary Pathobiochemistry Research Group Hungarian Academy of Sciences 1094 Budapest Hungary Department of Medical Chemistry Molecular Biology and Pathobiochemistry Semmelweis University 1094 Budapest Hungary Department of Pathophysiology Experimental Medicine and Public Health University of Siena 53100 Siena Italy 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2012年第4卷第4期

页      面：129-138页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences to Csala M 

主　　题：Metabolic syndrome Liver Glucocorticoid Glucose-6-phosphate-transporter Hexose-6-phosphate dehydrogenase 11β-hydroxysteroid dehydrogenase type 1 

摘      要：The metabolic syndrome, one of the most common clinical conditions in recent times, represents a combination of cardiometabolic risk determinants, including central obesity, glucose intolerance, insulin resistance, dyslipidemia, non-alcoholic fatty liver disease and hypertension. Prevalence of the metabolic syndrome is rapidly increasing worldwide as a consequence of common overnutrition and consequent obesity. Although a unifying picture of the pathomechanism is still missing, the key role of the pre-receptor glucocorticoid activation has emerged recently. Local glucocorticoid activation is catalyzed by a triad composed of glucose-6-phosphate-transporter, hexose-6-phosphate dehydrogenase and 11β-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum. The elements of this system can be found in various cell types, including adipocytes and hepatocytes. While the contribution of glucocorticoid activation in adipose tissue to the pathomechanism of the metabolic syndrome has been well established, the relative importance of the hepatic process is less understood. This review summarizes the available data on the role of the hepatic triad and its role in the metabolic syndrome, by confronting experimental findings with clinical observations.