Exploring the interplay of T cell receptor-V gene copy numbers and major histocompatibility complex selection pressure in avian species:Insights into immune system evolution and reproductive investment

作     者：Lin Sun Chunhong Liang Shidi Qin Ying Zhu Ke He 

作者机构：College of Animal Science and TechnologyCollege of Veterinary MedicineZhejiang Agriculture and Forestry UniversityKey Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang ProvinceZhejiang311300China Institute of Qinghai-Tibetan PlateauSouthwest Minzu UniversitySichuan610000China 

出 版 物：《Avian Research》 (鸟类学研究（英文版）)

年 卷 期：2024年第15卷第4期

页      面：503-511页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 0905[农学-畜牧学] 09[农学] 071007[理学-遗传学] 090501[农学-动物遗传育种与繁殖] 

基　　金：supported by the“Pioneer”and“Leading Goose”R&D Program of Zhejiang(No.2022C04014) Zhejiang Science and Technology Major Program on Agricultural New Variety Breeding(No.2021C02068-10) 

主　　题：Copy number variation Immune genes MHC selection pressure Pathogen selection TCR-V gene 

摘      要：Birds,a fascinating and diverse group occupying various habitats worldwide,exhibit a wide range of life-history traits,reproductive methods,and migratory behaviors,all of which influence their immune *** association between major histocompatibility complex(MHC)genes and certain ecological factors in response to pathogen selection has been extensively studied;however,the role of the co-working molecule T cell receptor(TCR)remains poorly *** study aimed to analyze the copy numbers of TCR-V genes,the selection pressure(ωvalue)on MHC genes using available genomic data,and their potential ecological correlates across 93 species from 13 *** study was conducted using the publicly available genome data of *** findings suggested that phylogeny influences the variability in TCR-V gene copy numbers and MHC selection *** phylogenetic generalized least squares regression model revealed that TCR-Vαδcopy number and MHC-I selection pressure were positively associated with body *** size was correlated with MHC selection pressure,and Migration was correlated with TCR-Vβcopy *** analyses revealed that the TCR-Vβcopy number was positively correlated with MHC-IIB selection pressure,while the TCR-Vγcopy number was negatively correlated with MHC-I peptide-binding region selection *** findings suggest that TCR-V diversity is significant in adaptive evolution and is related to species’life-history strategies and immunological defenses and provide valuable insights into the mechanisms underlying TCR-V gene duplication and MHC selection in avian species.