Immunotherapy of melanoma metastasis by adoptive transfer of M-CSF or/and IFN-γ gene modified macrophages pulsed with tumor extracts

作     者：Hong Lei, Yizhi Yu, Xuetao CaoDepartment of Immunology, The Second Military MedicalUniversity, Shanghai 200433 

出 版 物：《中国实验血液学杂志》 (Journal of Experimental Hematology)

年 卷 期：1997年第5卷第3期

页      面：312-312页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：melanoma macrophages Immunotherapy extracts metastasis infusion thereafter presentation Antigen Induction 

摘      要：Induction of tumor-specific cellular immune responseis very important in the cancer therapy. In this study,we used tumor antigen obtained by thaw of melanomacells to pulse M-CSF or/and IFN-γ gene-modificdmacrophages before in viro infusion. Tumor membraneantigens could be phagocytosed by macrophages inculture. Antigen processing and mcxlulation of thepresentation can be achieved before macrophageinjection. The tumor antigens will be processedintracellularly by macrophages and thereafter